An anionic long-circulating liposome that improves radioiodinated antisense oligonucleotide delivery in vitro and in vivo

被引：3

作者：

Xie, Jiawei ^{[2
]}

Ma, Chao ^{[1
]}

Lin, Jizheng ^{[3
]}

Wang, Guoming ^{[1
]}

Kuang, Anren ^{[4
]}

Zuo, Shuyao ^{[1
]}

机构：

[1] Qingdao Univ, Dept Nucl Med, Affiliated Hosp, Qingdao 266071, Shandong, Peoples R China

[2] Qingdao Univ, Dept Stomatol, Linyi Peoples Hosp, Linyi, Shandong, Peoples R China

[3] Qingdao Univ, Dept Radiol, Affiliated Hosp, Qingdao 266071, Shandong, Peoples R China

[4] Sichuan Univ, Dept Nucl Med, Affiliated Hosp, W China Hosp, Chengdu 610064, Sichuan Provinc, Peoples R China

来源：

ADVANCES IN POLYMER TECHNOLOGY | 2012年 / 31卷 / 01期

关键词：

Anionic polymerization; Particle size distribution; Radiation; BCL-2; ANTISENSE; BREAST-CANCER; DOXORUBICIN; PHARMACOKINETICS; APOPTOSIS;

D O I：

10.1002/adv.20231

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

This study reports the antitumor effects of radioiodinated antisense oligonucleotides (ASON) mediated by anionic long-circulating liposomes (ALCL) on MCF-7 breast cancer cells in vitro and the pharmacokinetics and tissue distribution of ALCL in vivo. Our results found that ALCL improves the delivery of radioiodinated ASON, characterized by significant apoptosis, decreased cell survival, and suppressed bcl-2 protein expression in MCF-7 cells. ALCL exhibited bicompartmental clearance and demonstrated significantly favorable pharmacokinetic properties including long half-life, slow clearance, and a large concentrationtime curve. (C) 2011 Wiley Periodicals, Inc. Adv Polym Techn 31: 2028, 2012; View this article online at . DOI 10.1002/adv.20231

引用

页码：20 / 28

页数：9

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