Parametric level set reconstruction methods for hyperspectral diffuse optical tomography

被引:18
|
作者
Larusson, Fridrik [1 ]
Fantini, Sergio [2 ]
Miller, Eric L. [1 ]
机构
[1] Tufts Univ, Dept Elect & Comp Engn, Medford, MA 02155 USA
[2] Tufts Univ, Dept Biomed Engn, Medford, MA 02155 USA
来源
BIOMEDICAL OPTICS EXPRESS | 2012年 / 3卷 / 05期
基金
美国国家卫生研究院;
关键词
CONTINUOUS-WAVE; FEMALE BREAST; TURBID MEDIA; IN-VIVO; SCATTERING; ABSORPTION; HEMOGLOBIN; TISSUE; SPECTROSCOPY; ALGORITHMS;
D O I
10.1364/BOE.3.001006
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
A parametric level set method (PaLS) is implemented for image reconstruction for hyperspectral diffuse optical tomography (DOT). Chromophore concentrations and diffusion amplitude are recovered using a linearized Born approximation model and employing data from over 100 wavelengths. The images to be recovered are taken to be piecewise constant and a newly introduced, shape-based model is used as the foundation for reconstruction. The PaLS method significantly reduces the number of unknowns relative to more traditional level-set reconstruction methods and has been show to be particularly well suited for ill-posed inverse problems such as the one of interest here. We report on reconstructions for multiple chromophores from simulated and experimental data where the PaLS method provides a more accurate estimation of chromophore concentrations compared to a pixel-based method. (c) 2012 Optical Society of America
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页码:1006 / 1024
页数:19
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