Neural correlates of emotional valence processing in Parkinson's disease: dysfunction in the subcortex

被引：18
作者：
Bell, Peter T. [1 ,2 ]
Gilat, Moran [1 ]
Shine, James M. [1 ]
McMahon, Katie L. [3 ]
Lewis, Simon J. G. [1 ]
Copland, David A. [2 ,4 ]
机构：
[1] Univ Sydney, Brain & Mind Ctr, Sydney, NSW, Australia
[2] Univ Queensland, Ctr Clin Res, Brisbane, Qld, Australia
[3] Univ Queensland, Ctr Adv Imaging, Brisbane, Qld, Australia
[4] Univ Queensland, Sch Hlth & Rehabil Sci, Brisbane, Qld, Australia
来源：
BRAIN IMAGING AND BEHAVIOR | 2019年 / 13卷 / 01期
基金：
澳大利亚研究理事会;
关键词：
Amygdala; Dopamine; Emotion; Parkinson's disease; Ventral striatum; STATE FUNCTIONAL CONNECTIVITY; GO/NO-GO TASK; TRYPTOPHAN DEPLETION; BASAL GANGLIA; AMYGDALA; BRAIN; DEPRESSION; STRIATUM; DOPAMINE; TRANSPORTER;
D O I：
10.1007/s11682-017-9754-3
中图分类号：
R445 [影像诊断学];
学科分类号：
100207 ;
摘要：
Parkinson's disease (PD) is frequently accompanied by cognitive and neuropsychiatric symptoms including impairments in affective processing. Despite this, mechanisms underlying vulnerability to deficits in affective processing remain unclear. In this study, we utilized functional Magnetic Resonance Imaging (fMRI) and an Affective Go-NoGo paradigm, to examine the neural correlates of emotional valence processing in PD. Results suggest that PD is associated with aberrant processing of emotional valence in subcortical limbic structures. Specifically, we found significant group-by-valence interactions in the ventral striatum and amygdala in response to words of differing emotional valence. Our findings contribute to a broader understanding of affective processing in PD and may provide insights into the mechanisms underlying vulnerability to mood disorders in PD.
引用
收藏
页码：189 / 199
页数：11
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