Frontal lobe structure and executive function in migraine patients

被引：142

作者：

Schmitz, Nicole ^{[1
]}

Arkink, Enrico B. ^{[1
]}

Mulder, Marieke ^{[1
]}

Rubia, Katya ^{[3
]}

Admiraal-Behloul, Faiza ^{[1
]}

Schoonmann, Guus G. ^{[2
]}

Kruit, Mark C. ^{[1
]}

Ferrari, Michel D. ^{[2
]}

van Buchem, Mark A. ^{[1
]}

机构：

[1] Leiden Univ, Med Ctr, Dept Radiol, NL-2300 RC Leiden, Netherlands

[2] Leiden Univ, Med Ctr, Dept Neurol, NL-2300 RC Leiden, Netherlands

[3] Kings Coll London, Inst Psychiat, London, England

来源：

NEUROSCIENCE LETTERS | 2008年 / 440卷 / 02期

关键词：

executive function; frontal cortex; magnetic resonance imaging (MRI); migraine;

D O I：

10.1016/j.neulet.2008.05.033

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Neuroimaging studies have identified frontal lobe brain abnormalities in migraineurs. Neuropsychological investigations highlighted frontal lobe related cognitive impairments in migraineurs, including working memory and executive function deficits. The relationship between brain anatomy and cognitive function in migraine, however, is unclear. The aim of this study was to simultaneously investigated cortex structure and executive function (EF) in patients with migraine and control subjects. Thus, we assessed grey matter (GM) density in 25 adult patients with migraine, compared to age and sex-matched control subjects, using magnetic resonance imaging (MRI) and voxel-based-morphometry (VBM), and we measured EF in the same population, employing three EF tasks of the Maudsley attention and response suppression (MARS) battery. Migraineurs, compared to control subjects, showed decreased frontal and parietal lobe GM density and slower response time to task set-shifting and, the delayed response time correlated significantly with reduced GM density of the frontal lobes in migraineurs. Frontal and parietal lobe abnormalities in migraineurs could be an underlying cause of significantly slower response time during cognitive setshifting. (c) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：92 / 96

页数：5

共 30 条

[1] Voxel-based morphometry - The methods [J].