Novel DOTA-based prochelator for divalent peptide vectorization: synthesis of dimeric bombesin analogues for multimodality tumor imaging and therapy

被引：42

作者：

Abiraj, Keelara ^{[1
]}

Jaccard, Hugues ^{[2
]}

Kretzschmar, Martin ^{[1
]}

Helm, Lothar ^{[2
]}

Maecke, Helmut R. ^{[1
]}

机构：

[1] Univ Basel Hosp, Dept Radiol, Div Radiol Chem, CH-4031 Basel, Switzerland

[2] EPFL BCH, Lab Chim Inorgan & Bioinorgan, CH-1015 Lausanne, Switzerland

来源：

CHEMICAL COMMUNICATIONS | 2008年 / 28期

关键词：

D O I：

10.1039/b805281f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Dimeric peptidic vectors, obtained by the divalent grafting of bombesin analogues on a newly synthesized DOTA-based prochelator, showed improved qualities as tumor targeted imaging probes in comparison to their monomeric analogues.

引用

页码：3248 / 3250

页数：3

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