Recent Advances in Metabolically Engineered Microorganisms for the Production of Aromatic Chemicals Derived From Aromatic Amino Acids

被引：38

作者：

Shen, Yu-Ping ^{[1
]}

Niu, Fu-Xing ^{[1
]}

Yan, Zhi-Bo ^{[1
]}

Fong, Lai San ^{[1
]}

Huang, Yuan-Bin ^{[1
]}

Liu, Jian-Zhong ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Guangdong Prov Key Lab Improved Variety Reprod Aq, Biomed Ctr, Sch Life Sci,Inst Synthet Biol, Guangzhou, Peoples R China

来源：

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY | 2020年 / 8卷

基金：

中国国家自然科学基金;

关键词：

aromatic amino acid derivatives; stilbenes; benzylisoquinoline alkaloids; metabolic engineering; microorganism; strain construction; P-COUMARIC ACID; TYROSINE AMMONIA-LYASE; DE-NOVO PRODUCTION; BIOBASED L-PHENYLALANINE; ESCHERICHIA-COLI; SACCHAROMYCES-CEREVISIAE; BIOSYNTHETIC-PATHWAY; CORYNEBACTERIUM-GLUTAMICUM; CAFFEIC ACID; L-DOPA;

D O I：

10.3389/fbioe.2020.00407

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Aromatic compounds derived from aromatic amino acids are an important class of diverse chemicals with a wide range of industrial and commercial applications. They are currently produced via petrochemical processes, which are not sustainable and eco-friendly. In the past decades, significant progress has been made in the construction of microbial cell factories capable of effectively converting renewable carbon sources into value-added aromatics. Here, we systematically and comprehensively review the recent advancements in metabolic engineering and synthetic biology in the microbial production of aromatic amino acid derivatives, stilbenes, and benzylisoquinoline alkaloids. The future outlook concerning the engineering of microbial cell factories for the production of aromatic compounds is also discussed.

引用

页数：43

共 167 条

[1] Metabolic Engineering of the Shikimate Pathway for Production of Aromatics and Derived Compounds-Present and Future Strain Construction Strategies [J].

Averesch, Nils J. H. ;

Kroemer, Jens O. .

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 2018, 6

[2] Production of salidroside in metabolically engineered Escherichia coli [J].

Bai, Yanfen ;

Bi, Huiping ;

Zhuang, Yibin ;

Liu, Chang ;

Cai, Tao ;

Liu, Xiaonan ;

Zhang, Xueli ;

Liu, Tao ;

Ma, Yanhe .

SCIENTIFIC REPORTS, 2014, 4

[3] Metabolic engineering for improving anthranilate synthesis from glucose in Escherichia coli [J].

Balderas-Hernandez, Victor E. ;

Sabido-Ramos, Andrea ;

Silva, Patricia ;

Cabrera-Valladares, Natividad ;

Hernandez-Chavez, Georgina ;

Baez-Viveros, Jose L. ;

Martinez, Alfredo ;

Bolivar, Francisco ;

Gosset, Guillermo .

MICROBIAL CELL FACTORIES, 2009, 8

[4] High-level production of trans-cinnamic acid by fed-batch cultivation of Escherichia coli [J].

Bang, Hyun Bae ;

Lee, Kyungsoo ;

Lee, Yong Jae ;

Jeong, Ki Jun .

PROCESS BIOCHEMISTRY, 2018, 68 :30-36

[5] Metabolic engineering of Saccharomyces cerevisiae for the synthesis of the wine-related antioxidant resveratrol [J].

Becker, JVW ;

Armstrong, GO ;

Van der Merwe, MJ ;

Lambrechts, MG ;

Vivier, MA ;

Pretorius, IS .

FEMS YEAST RESEARCH, 2003, 4 (01) :79-85

[6] Production of resveratrol in recombinant microorganisms [J].

Beekwilder, Jules ;

Wolswinkel, Rianne ;

Jonker, Harry ;

Hall, Robert ;

Ric de Vos, C. H. ;

Bovy, Arnaud .

APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2006, 72 (08) :5670-5672

[7] Construction of a Chimeric Biosynthetic Pathway for the De Novo Biosynthesis of Rosmarinic Acid in Escherichia coli [J].

Bloch, Sarah E. ;

Schmidt-Dannert, Claudia .

CHEMBIOCHEM, 2014, 15 (16) :2393-2401

[8] Broad-Host-Range ProUSER Vectors Enable Fast Characterization of Inducible Promoters and Optimization of p-Coumaric Acid Production in Pseudomonas putida KT2440 [J].

Calero, Patricia ;

Jensen, Sheila I. ;

Nielsen, Alex T. .

ACS SYNTHETIC BIOLOGY, 2016, 5 (07) :741-753

[9] Engineering of a microbial coculture of Escherichia coli strains for the biosynthesis of resveratrol [J].

Camacho-Zaragoza, Jose M. ;

Hernandez-Chavez, Georgina ;

Moreno-Avitia, Fabian ;

Ramirez-Iniguez, Rene ;

Martinez, Alfredo ;

Bolivar, Francisco ;

Gosset, Guillermo .

MICROBIAL CELL FACTORIES, 2016, 15

[10] Building microbial factories for the production of aromatic amino acid pathway derivatives: From commodity chemicals to plant-sourced natural products [J].

Cao, Mingfeng ;

Gao, Meirong ;

Suastegui, Miguel ;

Mei, Yanzhen ;

Shao, Zengyi .

METABOLIC ENGINEERING, 2020, 58 :94-132

← 1 2 3 4 5 6 7 8 9 10 →