Hodgkin Lymphoma in a Patient With IFAP Syndrome: A Case Report and Review of Literature

被引：4

作者：

Shakibazad, Nader ^{[1
]}

Shahriari, Mahdi ^{[1
]}

Inaloo, Soroor ^{[2
]}

机构：

[1] Shiraz Univ Med Sci, Dept Pediat, Div Pediat Hematol & Oncol, Shiraz 7193711351, Iran

[2] Shiraz Univ Med Sci, Neonatal Res Ctr, Shiraz, Iran

来源：

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY | 2018年 / 40卷 / 03期

关键词：

IFAP syndrome; hodgkin lymphoma; MBTPS2; gene; ICHTHYOSIS FOLLICULARIS; ALOPECIA; MBTPS2; MANIFESTATIONS; MUTATION;

D O I：

10.1097/MPH.0000000000000894

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The IFAP syndrome is a rare X-linked recessive inheritance disorder with defect of the MBTPS2 gene defined by the triad of follicular ichthyosis, alopecia, and photophobia. A total of 40 cases has been reported, but no correlation with Hodgkin lymphoma has been reported yet. A 3.5-year-old boy was diagnosed with IFAP syndrome confirmed by Next Generation Sequencing. He was on regular follow-up when he developed prolonged fever and lymphadenopathy. His lymph node biopsy showed Hodgkin lymphoma with mixed cellularity subtype. This case is the first report on IFAP syndrome associated with malignancy. IFAP syndrome could be a risk factor in developing malignancy.

引用

页码：227 / 230

页数：4

共 14 条

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