Blood amyloid and tau biomarkers as predictors of cerebrospinal fluid profiles

被引：14

作者：

Delaby, Constance ^{[1
,2
]}

Alcolea, Daniel ^{[2
]}

Hirtz, Christophe ^{[1
]}

Vialaret, Jerome ^{[1
]}

Kindermans, Jana ^{[1
]}

Morichon, Lisa ^{[1
]}

Fortea, Juan ^{[2
]}

Belbin, Olivia ^{[2
]}

Gabelle, Audrey ^{[3
]}

Blennow, Kaj ^{[4
,5
]}

Zetterberg, Henrik ^{[4
,5
,6
,7
,8
]}

Lleo, Alberto ^{[2
]}

Lehmann, Sylvain ^{[1
]}

机构：

[1] Univ Montpellier, Lab Biochim Proteom Clin LBPC PPC, Hop St Eloi, INM INSERM,CHU Montpellier, IRMB 80 Av A Fliche, F-34295 Montpellier, France

[2] Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Biomed Res Inst St Pau, Barcelona, Spain

[3] Univ Montpellier, INM INSERM, CHU Montpellier, CMRR, Montpellier, France

[4] Univ Gothenburg, Inst Neurosci & Physiol, Dept Psychiat & Neurochem, Sahlgrenska Acad, Gothenburg, Sweden

[5] Sahlgrens Univ Hosp, Clin Neurochem Lab, Molndal, Sweden

[6] UCL Inst Neurol, Dept Neurodegenerat Dis, Queen Sq, London, England

[7] UK Dementia Res Inst UCL, London, England

[8] Hong Kong Ctr Neurodegenerat Dis, Hong Kong, Peoples R China

来源：

JOURNAL OF NEURAL TRANSMISSION | 2022年 / 129卷 / 02期

基金：

瑞典研究理事会; 欧盟地平线“2020”;

关键词：

Blood; Biomarkers; Clinical management; Lumbar puncture; CSF; ALZHEIMERS-DISEASE; BETA;

D O I：

10.1007/s00702-022-02474-9

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction Blood biomarkers represent a major advance for improving the management, diagnosis, and monitoring of Alzheimer's disease (AD). However, their context of use in relation to routine cerebrospinal fluid (CSF) analysis for the quantification of amyloid peptides and tau proteins remains to be determined. Methods We studied in two independent cohorts, the performance of blood biomarkers in detecting "nonpathological" (A-/T-/N-), amyloid (A+) or neurodegenerative (T+ /N+) CSF profiles. Results Plasma A beta(1-42)/A beta(1-40) ratio and phosphorylated tau (p-tau(181)) were independent and complementary predictors of the different CSF profile and in particular of the nonpathological (A-/T-/N-) profile with a sensitivity and specificity close to 85%. These performances and the corresponding biomarker thresholds were significantly different from those related to AD detection. Conclusion The use of blood biomarkers to identify patients who may benefit from secondary CSF testing represents an attractive stratification strategy in the clinical management of patients visiting memory clinics. This could reduce the need for lumbar puncture and foreshadow the use of blood testing on larger populations.

引用

页码：231 / 237

页数：7

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