Factors Affecting Growth in Infants with Single Ventricle Physiology: A Report from the Pediatric Heart Network Infant Single Ventricle Trial

被引：85

作者：

Williams, Richard V. ^{[1
]}

Zak, Victor ^{[3
]}

Ravishankar, Chitra ^{[4
]}

Altmann, Karen ^{[5
]}

Anderson, Jeffrey ^{[6
]}

Atz, Andrew M. ^{[7
]}

Dunbar-Masterson, Carolyn ^{[8
]}

Ghanayem, Nancy ^{[9
]}

Lambert, Linda ^{[2
]}

Lurito, Karen ^{[10
]}

Medoff-Cooper, Barbara ^{[4
,11
]}

Margossian, Renee ^{[8
]}

Pemberton, Victoria L. ^{[12
]}

Russell, Jennifer ^{[13
]}

Stylianou, Mario ^{[12
]}

Hsu, Daphne ^{[5
]}

机构：

[1] Univ Utah, Dept Pediat, Salt Lake City, UT USA

[2] Univ Utah, Dept Surg, Salt Lake City, UT USA

[3] New England Res Inst, Watertown, MA 02172 USA

[4] Childrens Hosp Philadelphia, Dept Pediat, Philadelphia, PA 19104 USA

[5] Childrens Hosp New York, Dept Pediat, New York, NY USA

[6] Univ Cincinnati, Dept Pediat, Cincinnati, OH 45221 USA

[7] Med Univ S Carolina, Dept Pediat, Charleston, SC 29425 USA

[8] Childrens Hosp, Dept Cardiol, Boston, MA 02115 USA

[9] Med Coll Wisconsin, Dept Pediat, Milwaukee, WI 53226 USA

[10] E Carolina Univ, Dept Pediat, Greenville, NC USA

[11] Univ Penn, Sch Nursing, Philadelphia, PA 19104 USA

[12] NHLBI, NIH, Bethesda, MD 20892 USA

[13] Hosp Sick Children, Dept Pediat, Toronto, ON M5G 1X8, Canada

来源：

JOURNAL OF PEDIATRICS | 2011年 / 159卷 / 06期

关键词：

ENERGY-EXPENDITURE; NUTRITIONAL-STATUS; SOMATIC GROWTH; DISEASE; CHILDREN; FAILURE; MALNUTRITION;

D O I：

10.1016/j.jpeds.2011.05.051

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Objectives To describe growth patterns in infants with single ventricle physiology and determine factors influencing growth. Study design Data from 230 subjects enrolled in the Pediatric Heart Network Infant Single Ventricle Enalapril Trial were used to assess factors influencing change in weight-for-age z-score (z) from study enrollment (0.7 +/- 0.4 months) to pre-superior cavopulmonary connection (SCPC; 5.1 +/- 1.8 months, period 1) and pre-SCPC to final study visit (14.1 +/- 0.9 months, period 2). Predictor variables included patient characteristics, feeding regimen, clinical center, and medical factors during neonatal (period 1) and SCPC hospitalizations (period 2). Univariate regression analysis was performed, followed by backward stepwise regression and bootstrapping reliability to inform a final multivariable model. Results Weights were available for 197 of 230 subjects for period 1 and 173 of 197 subjects for period 2. For period 1, greater gestational age, younger age at study enrollment, tube feeding at neonatal hospitalization discharge, and clinical center were associated with a greater negative z (poorer growth) in multivariable modeling (adjusted R(2) = 0.39, P < .001). For period 2, younger age at SCPC and greater daily caloric intake were associated with greater positive z (better growth; R(2) = 0.10, P = .002). Conclusions Aggressive nutritional support and earlier SCPC are modifiable factors associated with a favorable change in weight-for-age z-score. (J Pediatr 2011;159:1017-22).

引用

页码：1017 / U189

页数：8

共 21 条

[1] Predictors of Poor Weight Gain in Infants with a Single Ventricle [J].