Characterization of the lung tumor microenvironment upon anti-PD-L1 therapy reveals an ambiguous role for TNF-α

被引:0
|
作者
De Ridder, K. [1 ]
Locy, H. [1 ]
Piccioni, E. [1 ]
Zuazo, M. Ibarra [2 ]
Awad, R. M. [1 ]
Verhulst, S. [3 ,4 ]
van Bulck, M. [5 ]
De Vlaeminck, Y. [1 ]
Lecocq, Q. [1 ]
Reijmen, E. [1 ]
De Mey, W. [1 ]
De Beck, L.
Ertveldt, T. [1 ]
Pintelon, I. [6 ]
Timmermans, J-P. [6 ]
Escors, D. [2 ]
Keyaerts, M. [7 ]
Breckpot, K. [1 ]
Goyvaerts, C. [1 ]
机构
[1] Vrije Univ Brussel, Fac Med & Pharm, Dept Biomed Sci, Lab Mol & Cellular Therapy, Brussels, Belgium
[2] Navarrabiomed UPNA IdISNA, Immunomodulat Grp, Pamplona, Spain
[3] Dept Biomed Sci, Brussels, Belgium
[4] Liver Cell Biol Res Grp, Jette, Belgium
[5] Vrije Univ Brussel, Dept Biomed Sci, Lab Mol & Med Oncol, Jette, Belgium
[6] Univ Antwerp, Antwerp Ctr Adv Microscopy ACAM, Lab Cell Biol & Histol, Antwerp, Belgium
[7] Vrije Univ Brussel, Fac Med & Pharm, Invivo Cellular & Mol Imaging Lab, Jette, Belgium
关键词
D O I
10.1016/j.annonc.2022.02.200
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
168P
引用
收藏
页码:S109 / S109
页数:1
相关论文
共 50 条
  • [21] Anti-PD-L1 therapy: patient selection is important
    Peter Sidaway
    Nature Reviews Clinical Oncology, 2016, 13 (3) : 134 - 134
  • [22] Discordance Among Biomarkers for Anti-PD1 Therapy Response: Tumor Mutational Burden and Anti-PD-L1 Staining
    Hess, P. R.
    Velu, P. D.
    Bigdeli, A.
    Morrissette, J. J.
    Rosenbaum, J. N.
    Roth, J.
    JOURNAL OF MOLECULAR DIAGNOSTICS, 2017, 19 (06): : 1039 - 1039
  • [23] Acidic tumor microenvironment-activated MRI nanoprobes for modulation and visualization of anti-PD-L1 immunotherapy
    Fan, Kai
    Yang, Xue
    Tian, Fang-zheng
    Li, Si-yu
    Zhang, Jian-qiong
    Xie, Jin-bing
    Ju, Sheng-hong
    NANO TODAY, 2024, 54
  • [24] Current state of anti-PD-L1 and anti-PD-1 agents in cancer therapy
    Swaika, Abhisek
    Hammond, William A.
    Joseph, Richard W.
    MOLECULAR IMMUNOLOGY, 2015, 67 (02) : 4 - 17
  • [25] New insights into the anti-PD-L1 and anti-PD-1 reagents in cancer therapy
    Chen, Cheng
    Huang, Jian-An
    EUROPEAN JOURNAL OF INFLAMMATION, 2016, 14 (01) : 61 - 65
  • [26] Parameters of Tumor Microenvironment Determine Effectiveness of Anti-PD-1/PD-L1 Therapy
    Tashireva, Liubov A.
    Muravyova, Dariya T.
    Popova, Natalya O.
    Goldberg, Victor E.
    Vtorushin, Sergey V.
    Perelmuter, Vladimir M.
    BIOCHEMISTRY-MOSCOW, 2021, 86 (11) : 1461 - 1468
  • [27] Parameters of Tumor Microenvironment Determine Effectiveness of Anti-PD-1/PD-L1 Therapy
    Liubov A. Tashireva
    Dariya T. Muravyova
    Natalya O. Popova
    Victor E. Goldberg
    Sergey V. Vtorushin
    Vladimir M. Perelmuter
    Biochemistry (Moscow), 2021, 86 : 1461 - 1468
  • [28] A rare case of pneumocystosis under anti-PD-L1 therapy
    Santos, Maria Joao
    Cavaco, Maria Joao
    Santos, Fernanda Paula
    Froes, Filipe
    PULMONOLOGY, 2024, 30 (06): : 671 - 672
  • [29] Huaier improves the efficacy of anti-PD-L1 Ab in the treatment of hepatocellular carcinoma by regulating tumor immune microenvironment
    Li, Huawei
    You, Jia
    Wei, Yuanfeng
    Zheng, Lingnan
    Yang, Ju
    Xu, Jingyi
    Li, Yue
    Li, Zhaojun
    Yang, Xi
    Yi, Cheng
    PHYTOMEDICINE, 2024, 123
  • [30] Targeting pulmonary tumor microenvironment with CXCR4-inhibiting nanocomplex to enhance anti-PD-L1 immunotherapy
    Li, Zhaoting
    Wang, Yixin
    Shen, Yuexin
    Qian, Chenggen
    Oupicky, David
    Sun, Minjie
    SCIENCE ADVANCES, 2020, 6 (20):