Neurotoxic non-proteinogenic amino acid β-N-methylamino-L-alanine and its role in biological systems

被引：18

作者：

Popova, A. A. ^{[1
]}

Koksharova, O. A. ^{[1
,2
]}

机构：

[1] Russian Acad Sci, Inst Mol Genet, Moscow 123182, Russia

[2] Lomonosov Moscow State Univ, Belozersky Inst Physicochem Biol, Moscow 119991, Russia

来源：

BIOCHEMISTRY-MOSCOW | 2016年 / 81卷 / 08期

基金：

俄罗斯基础研究基金会;

关键词：

BMAA (beta-N-methylamino-L-alanine); cyanobacteria; cyanotoxins; neurotoxins; apoptosis; oxidative stress; neurodegenerative diseases; AMYOTROPHIC-LATERAL-SCLEROSIS; PARKINSONISM-DEMENTIA COMPLEX; PROGRAMMED CELL-DEATH; CYANOBACTERIAL NEUROTOXIN; NEURODEGENERATIVE DISEASE; DIAZOTROPHIC GROWTH; NEONATAL EXPOSURE; CYCAD NEUROTOXIN; L-BMAA; IDENTIFICATION;

D O I：

10.1134/S0006297916080022

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Secondary metabolites of photoautotrophic organisms have attracted considerable interest in recent years. In particular, molecules of non-proteinogenic amino acids participating in various physiological processes and capable of producing adverse ecological effects have been actively investigated. For example, the non-proteinogenic amino acid beta-Nmethylamino-L-alanine (BMAA) is neurotoxic to animals including humans. It is known that BMAA accumulation via the food chain can lead to development of neurodegenerative diseases in humans such as Alzheimer's and Parkinson's diseases as well as amyotrophic lateral sclerosis. Moreover, BMAA can be mistakenly incorporated into a protein molecule instead of serine. Natural sources of BMAA and methods for its detection are discussed in this review, as well as the role of BMAA in metabolism of its producers and possible mechanisms of toxicity of this amino acid in different living organisms.

引用

页码：794 / 805

页数：12

共 110 条

[31] A potential physiological role for cyanotoxins in cyanobacteria of arid environments [J].

Downing, T. G. ;

Phelan, R. R. ;

Downing, S. .

JOURNAL OF ARID ENVIRONMENTS, 2015, 112 :147-151

[32]

DUNCAN MW, 1991, J PHARMACOL EXP THER, V258, P27

[33]

DUNCAN MW, 1991, ADV NEUROL, V56, P301

[34] The Non-Protein Amino Acid BMAA Is Misincorporated into Human Proteins in Place of L-Serine Causing Protein Misfolding and Aggregation [J].

Dunlop, Rachael Anne ;

Cox, Paul Alan ;

Banack, Sandra Anne ;

Rodgers, Kenneth John .

PLOS ONE, 2013, 8 (09)

[35] β-N-methylamino-L-alanine (BMAA) in novel South African cyanobacterial isolates [J].

Esterhuizen, M. ;

Downing, T. G. .

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2008, 71 (02) :309-313

[36] β-N-Methylamino-L-alanine (BMAA) uptake by the aquatic macrophyte Ceratophyllum demersum [J].

Esterhuizen, M. ;

Pflugmacher, S. ;

Downing, T. G. .

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2011, 74 (01) :74-77

[37] The effect of β-N-methylamino-L-alanine (BMAA) on oxidative stress response enzymes of the macrophyte Ceratophyllum demersum [J].

Esterhuizen-Londt, M. ;

Pflugmacher, S. ;

Downing, T. G. .

TOXICON, 2011, 57 (05) :803-810

[38] Presence of the Neurotoxin BMAA in Aquatic Ecosystems: What Do We Really Know? [J].

Faassen, Elisabeth J. .

TOXINS, 2014, 6 (03) :1109-1138

[39] A Comparative Study on Three Analytical Methods for the Determination of the Neurotoxin BMAA in Cyanobacteria [J].

Faassen, Elisabeth J. ;

Gillissen, Frits ;

Luerling, Miquel .

PLOS ONE, 2012, 7 (05)

[40] Determination of the neurotoxins BMAA (β-N-methylamino-L-alanine) and DAB (α-,γ-diaminobutyric acid) by LC-MSMS in Dutch urban waters with cyanobacterial blooms [J].

Faassen, Elisabeth J. ;

Gillissen, Frits ;

Zweers, Hans A. J. ;

Lurling, Miquel .

AMYOTROPHIC LATERAL SCLEROSIS, 2009, 10 :79-84

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