Current pharmacological treatments for COVID-19: What's next?

被引：189

作者：

Scavone, Cristina ^{[1
]}

Brusco, Simona ^{[1
]}

Bertini, Michele ^{[1
]}

Sportiello, Liberata ^{[1
]}

Rafaniello, Concetta ^{[1
]}

Zoccoli, Alice ^{[2
]}

Berrino, Liberato ^{[1
]}

Racagni, Giorgio ^{[3
]}

Rossi, Francesco ^{[1
,2
]}

Capuano, Annalisa ^{[1
]}

机构：

[1] Univ Campania Luigi Vanvitelli, Dept Expt Med, Naples, Italy

[2] Univ Campus Biomed, Clin Innovat Off, Rome, Italy

[3] Univ Milan, Dept Pharmacol & Biomol Sci, Milan, Italy

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 2020年 / 177卷 / 21期

关键词：

VASOACTIVE-INTESTINAL-PEPTIDE; ACUTE RESPIRATORY SYNDROME; SYNDROME CORONAVIRUS; THALIDOMIDE ANALOGS; ANTIVIRAL ACTIVITY; CONCISE GUIDE; IN-VITRO; CHLOROQUINE; COLCHICINE; REMDESIVIR;

D O I：

10.1111/bph.15072

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Since December 2019 SARS-Cov-2 was found responsible for the disease COVID-19, which has spread worldwide. No specific therapies/vaccines are yet available for the treatment of COVID-19. Drug repositioning may offer a strategy and a number of drugs have been repurposed, including lopinavir/ritonavir, remdesivir, favipiravir and tocilizumab. This paper describes the main pharmacological properties of such drugs administered to patients with COVID-19, focusing on their antiviral, immune-modulatory and/or anti-inflammatory actions. Where available, data from clinical trials involving patients with COVID-19 are reported. Preliminary clinical trials seem to support their benefit. However, such drugs in COVID-19 patients have peculiar safety profiles. Thus, adequate clinical trials are necessary for these compounds. Nevertheless, while waiting for effective preventive measures i.e. vaccines, many clinical trials on drugs belonging to different therapeutic classes are currently underway. Their results will help us in defining the best way to treat COVID-19 and reducing its symptoms and complications.

引用

页码：4813 / 4824

页数：12

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