Synthesis of Tetraazamacrocyclic Crown Ether Ni(II) Complex and Electrochemical Study of its Interaction with DNA

A tetrazamacrocyclic crown ether complex of Ni(II) with the composition [NiL](ClO(4))(2) (L = 5,12-dimethyl-7,14-diphenyl-1,4,8,11-tetraazamacrocyclotetralecane) was synthesized and characterized by IR spectra and elemental analysis. The mutual effects of the [NiL](ClO(4))(2) with DNA were studied by electrochemical method. In the presence of DNA, the redox peaks of [NiL](ClO(4))(2) shifted to more positive values and the peak current increased greatly. The experimental results demonstrate that the [NiL](ClO(4))(2) could interact with DNA by intercalation binding mode.