Carbapenem Resistance Conferred by OXA-48 in K2-ST86 Hypervirulent Klebsiella pneumoniae, France

被引:27
作者
Beyrouthy, Racha [1 ,2 ,3 ,4 ]
Dalmasso, Guillaume [1 ,4 ,5 ]
Birer, Aurelien [2 ]
Robin, Frederic [1 ,2 ,3 ,4 ,5 ]
Bonnet, Richard [1 ,2 ,3 ,4 ,5 ]
机构
[1] INSERM, Clermont Ferrand, France
[2] Ctr Natl Reference Resistance Antibiot, Clermont Ferrand, France
[3] Ctr Hosp Univ, Clermont Ferrand, France
[4] INRA, USC 2018, Clermont Ferrand, France
[5] Univ Clermont Auvergne, Clermont Ferrand, France
关键词
D O I
10.3201/eid2607.191490
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
We recovered 2 carbapenem-resistant K2-ST86 hypermucoviscous Klebsiella pneumoniae isolates from patients in France. The isolates had genetic attributes of hypervirulent K. pneumoniae but differed in ability to cause mouse lethality. Convergence of hypervirulent K. pneumoniae toward resistance could cause a health crisis because such strains could be responsible for severe and untreatable infections.
引用
收藏
页码:1529 / 1533
页数:5
相关论文
共 15 条
  • [1] Novel Enterobacter Lineage as Leading Cause of Nosocomial Outbreak Involving Carbapenemase-Producing Strains
    Beyrouthy, Racha
    Barets, Marion
    Marion, Elodie
    Dananche, Cedric
    Dauwalder, Olivier
    Robin, Frederic
    Gauthier, Lauraine
    Jousset, Agnes
    Dortet, Laurent
    Guerin, Francois
    Benet, Thomas
    Cassier, Pierre
    Vanhems, Philippe
    Bonnet, Richard
    [J]. EMERGING INFECTIOUS DISEASES, 2018, 24 (08) : 1505 - 1515
  • [2] Chromosome-mediated OXA-48 carbapenemase in highly virulent Escherichia coli
    Beyrouthy, Racha
    Robin, Frederic
    Cougnoux, Antony
    Dalmasso, Guillaume
    Darfeuille-Michaud, Arlette
    Mallat, Hassan
    Dabboussi, Fouad
    Hamze, Monzer
    Bonnet, Richard
    [J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2013, 68 (07) : 1558 - 1561
  • [3] Sequencing and analysis of the large virulence plasmid pLVPK of Klebsiella pneumoniae CG43
    Chen, YT
    Chang, HY
    Lai, YC
    Pan, CC
    Tsai, SF
    Peng, HL
    [J]. GENE, 2004, 337 : 189 - 198
  • [4] The role of Klebsiella pneumoniae rmpA in capsular polysaccharide synthesis and virulence revisited
    Hsu, Chun-Ru
    Lin, Tzu-Lung
    Chen, You-Ci
    Chou, Huei-Chi
    Wang, Jin-Town
    [J]. MICROBIOLOGY-SGM, 2011, 157 : 3446 - 3457
  • [5] Karlsson M, 2019, ANTIMICROB AGENTS CH, V63, DOI [10.1128/AAC.00519-19, 10.1128/aac.00519-19]
  • [6] Genetic diversity, mobilisation and spread of the yersiniabactin-encoding mobile element ICEKp in Klebsiella pneumoniae populations
    Lam, Margaret M. C.
    Wick, Ryan R.
    Wyres, Kelly L.
    Gorrie, Claire L.
    Judd, Louise M.
    Jenney, Adam W. J.
    Brisse, Sylvain
    Holt, Kathryn E.
    [J]. MICROBIAL GENOMICS, 2018, 4 (09):
  • [7] Antimicrobial Resistance of Hypervirulent Klebsiella pneumoniae: Epidemiology, Hypervirulence-Associated Determinants, and Resistance Mechanisms
    Lee, Chang-Ro
    Lee, Jung Hun
    Park, Kwang Seung
    Jeon, Jeong Ho
    Kim, Young Bae
    Cha, Chang-Jun
    Jeong, Byeong Chul
    Lee, Sang Hee
    [J]. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 2017, 7
  • [8] Mataseje LF, 2019, ANTIMICROB AGENTS CH, V63, DOI [10.1128/aac.00517-19, 10.1128/AAC.00517-19]
  • [9] Incidence, Risk Factors, and Outcomes of Klebsiella pneumoniae Bacteremia
    Meatherall, Bonnie L.
    Gregson, Daniel
    Ross, Terry
    Pitout, Johann D. D.
    Laupland, Kevin B.
    [J]. AMERICAN JOURNAL OF MEDICINE, 2009, 122 (09) : 866 - 873
  • [10] Prokesch Bonnie C, 2016, Lancet Infect Dis, V16, pe190, DOI 10.1016/S1473-3099(16)30021-4