Further studies on the reaction of ethyl benzoylacetate with malononitrile: synthesis of some novel pyridine and pyridazine derivatives

被引：18

作者：

Abdelrazek, FM ^{[1
]}

El-Din, AMS ^{[1
]}

Mekky, AE ^{[1
]}

机构：

[1] Cairo Univ, Fac Sci, Dept Chem, Giza, Egypt

来源：

TETRAHEDRON | 2001年 / 57卷 / 31期

关键词：

nicotinonitriles; azo derivatives; pyridazines;

D O I：

10.1016/S0040-4020(01)00613-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2-Cyano-5-phenyl-3,5-dioxopentanonitrile undergoes alcoholysis followed by Knoevenagel condensation to afford ethyl 4,4-dicyano-3-phenyl-3-butenoate, a thermo dynamically controlled product, which undergoes cyclization in acid medium to afford 2,6-dihydroxy-4-phenylnicotinonitrile. Some azo derivatives of nicotinonitriles and of 2-aminopyran are described. 5-Arylazo-2-aminopyrans are transformed by acid treatment into pyridazine derivatives, whereas without the arylazo substituent pyridines are obtained. (C) 2001 Elsevier Science Ltd. All rights reserved.

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收藏

页码：6787 / 6791

页数：5

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