Peroxidase substrate nanosensors for MR imaging

被引：118

作者：

Perez, JM ^{[1
]}

Simeone, FJ ^{[1
]}

Tsourkas, A ^{[1
]}

Josephson, L ^{[1
]}

Weissleder, R ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, MGH Ctr Mol Imaging Res, Charlestown, MA 02129 USA

来源：

NANO LETTERS | 2004年 / 4卷 / 01期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1021/nl034983k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Magnetic nanoparticle conjugates that self-assemble in the presence of peroxidases were prepared as having large inducible magnetic resonance signals. When a serotonin-nanoparticle conjugate was incubated with myeloperoxidase, an enzyme implicated with inflammation and coronary diseases, there were significant changes in the T2 relaxation times of the solution, as measured by MRI. These nanoparticle conjugates can potentially serve as an in vivo diagnostic tool to identify peroxidase-induced diseases by MRI.

引用

页码：119 / 122

页数：4

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