The Role of Vitamin D in Diabetic Nephropathy: A Translational Approach

被引：20
作者：
Delrue, Charlotte [1 ]
Speeckaert, Reinhart [2 ]
Delanghe, Joris R. [3 ]
Speeckaert, Marijn M. [1 ,4 ]
机构：
[1] Ghent Univ Hosp, Dept Nephrol, B-9000 Ghent, Belgium
[2] Ghent Univ Hosp, Dept Dermatol, B-9000 Ghent, Belgium
[3] Univ Ghent, Dept Diagnost Sci, B-9000 Ghent, Belgium
[4] Res Fdn Flanders FWO, B-1000 Brussels, Belgium
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2022年 / 23卷 / 02期
关键词：
diabetes mellitus; diabetic nephropathy; vitamin D; D-RECEPTOR GENE; SERUM 25-HYDROXYVITAMIN D; D-BINDING PROTEIN; D DEFICIENCY; KIDNEY-DISEASE; MICROVASCULAR COMPLICATIONS; PODOCYTE INJURY; D ANALOG; 1,25-DIHYDROXYVITAMIN D-3; ENDOTHELIAL FUNCTION;
D O I：
10.3390/ijms23020807
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
According to several animal and human studies, vitamin D appears to play a significant role in the development of diabetic nephropathy. However, the possible renoprotective effect of vitamin D and its influence on the reversal of already existing renal damage remains doubtful. At this moment, there are a few hypotheses concerning the underlying molecular and genetic mechanisms including the link between vitamin D and inflammation, oxidative stress, and extracellular matrix accumulation. The present review aims to investigate the potential role of vitamin D in the development of diabetic kidney disease from a translational approach.
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页数：17
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