Low Graft Invariant Natural Killer T-Cell Dose Is a Risk Factor for Cytomegalovirus Reactivation After Allogeneic Hematopoietic Cell Transplantation

被引：3

作者：

Schneidawind, Dominik ^{[1
]}

Duerr-Stoerzer, Silke ^{[1
]}

Liewer, Sonja ^{[1
]}

Renner, Susanne ^{[1
]}

Navarro, Beatriz Sanchez ^{[1
]}

Atar, Daniel ^{[2
]}

Keppeler, Hildegard ^{[1
]}

Beck, Robert ^{[3
]}

Hamprecht, Klaus ^{[3
]}

Kanz, Lothar ^{[1
]}

Lengerke, Claudia ^{[1
]}

Schneidawind, Corina ^{[1
]}

机构：

[1] Univ Hosp Tuebingen, Dept Med 2, Otfried Mueller Str 10, D-72076 Tubingen, Germany

[2] Univ Childrens Hosp Tuebingen, Dept Gen Pediat Hematol & Oncol, Tubingen, Germany

[3] Univ Hosp Tuebingen, Inst Med Virol & Epidemiol Viral Dis, Tubingen, Germany

来源：

TRANSPLANTATION AND CELLULAR THERAPY | 2022年 / 28卷 / 08期

基金：

美国国家卫生研究院;

关键词：

Hematopoietic cell transplantation; Infectious complications; Innate immunity; VERSUS-HOST-DISEASE; STEM-CELL; INFECTION; PREDICTS;

D O I：

10.1016/j.jtct.2022.05.011

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cytomegalovirus (CMV) reactivation is common after allogeneic hematopoietic cell transplantation (HCT) and may result in fatal CMV disease. Invariant natural killer T (iNKT) cells are potent modulators of the immune system preventing graft-versus-host disease while promoting graft-versus-leukemia effects. It is thought that iNKT cells selectively influence mediators of both innate and adaptive immunity. Here, we investigated the impact of graft iNKT cells on CMV reactivation in patients undergoing allogeneic HCT. We found a significantly decreased cumula-tive incidence of CMV reactivation in patients with higher numbers of iNKT cells in the allograft. Therefore iNKT-cell-enriched grafts or adoptive transfer of iNKT cells are compelling cytotherapeutic strategies to improve out-comes after allogeneic HCT. (c) 2022 The American Society for Transplantation and Cellular Therapy. Published by Elsevier Inc. All rights reserved.

引用

页码：513.e1 / 513.e4

页数：4

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