Potent triazine-based dehydrocondensing reagents substituted by an amido group

被引：11

作者：

Kunishima, Munetaka ^{[1
]}

Kato, Daiki ^{[1
]}

Kimura, Nobu ^{[1
]}

Kitamura, Masanori ^{[1
]}

Yamada, Kohei ^{[1
]}

Hioki, Kazuhito ^{[2
]}

机构：

[1] Kanazawa Univ, Inst Med Pharmaceut & Hlth Sci, Fac Pharmaceut Sci, Kakuma Machi, Kanazawa, Ishikawa 9201192, Japan

[2] Kobe Gakuin Univ, Fac Pharmaceut Sci, Chuo Ku, 1-1-3 Minatojima, Kobe, Hyogo 6558586, Japan

来源：

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY | 2016年 / 12卷

关键词：

amide-forming reactions; amido substituents; dehydrocondensing reactions; Fischer-type esterification; triazines; COUPLING REAGENTS; CONDENSING AGENT; CARBOXYLIC-ACIDS; CHLORIDE; AMINES;

D O I：

10.3762/bjoc.12.179

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This study describes the synthesis of triazine-based dehydrocondensing reagents substituted by amido substituents and demonstrates their efficiency for dehydrocondensing reactions in MeOH and THF. N-Phenylbenzamido- substituted chlorotriazine is readily converted to a stable, non-hygroscopic triazinylammonium-based dehydrocondensing reagent that is superior to 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride (DMT-MM) in terms of its reactivity in dehydrocondensing reactions.

引用

页码：1897 / 1903

页数：7

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