CARDIODETECT RAPID TEST FOR THE DIAGNOSIS OF EARLY ACUTE MYOCARDIAL INFARCTION

被引：11

作者：

Liang, Yan ^{[1
,2
]}

Chan, Cangel P. Y. ^{[3
]}

Cheung, Kwan-yee ^{[4
]}

Cautherley, George W. H. ^{[4
]}

Glatz, Jan F. C. ^{[5
]}

Renneberg, Reinhard ^{[6
]}

Zhu, Jun ^{[1
,2
]}

机构：

[1] Chinese Acad Med Sci, Dept Emergency, Cardiovasc Inst, Peking Union Med Coll, Beijing 100037, Peoples R China

[2] Chinese Acad Med Sci, FuWai Hosp, Peking Union Med Coll, Beijing 100037, Peoples R China

[3] Chinese Univ Hong Kong, Accid & Emergency Med Acad Unit, Prince Wales Hosp, Hong Kong, Hong Kong, Peoples R China

[4] R&C Biogenius Ltd, Hong Kong, Hong Kong, Peoples R China

[5] Maastricht Univ, Dept Mol Genet, Cardiovasc Res Inst Maastricht, Maastricht, Netherlands

[6] Hong Kong Univ Sci & Technol, Dept Chem, Hong Kong, Hong Kong, Peoples R China

来源：

JOURNAL OF IMMUNOASSAY & IMMUNOCHEMISTRY | 2011年 / 32卷 / 04期

关键词：

acute myocardial infarction; cardiac marker; cardiac troponin I; diagnosis; heart-type fatty acid-binding protein; myoglobin; ACID-BINDING PROTEIN; TISSUE-INJURY; MARKERS; IMMUNOSENSORS; IMMUNOTESTS;

D O I：

10.1080/15321819.2011.573043

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Two hundreds patients suspected of acute myocardial infarction presenting to the hospital with a median symptom onset of 2.3 h (IQR 1.7-4.0 h) were enrolled in this study. The diagnostic performances of CardioDetect (R), a one-step immunotest for heart-type fatty acid-binding protein (H-FABP), and its combination with cardiac troponin I (cTnI) at admission and 2 h after admission, were compared with different cardiac markers. The H-FABP immunotest had better sensitivities (76.6% and 94.4%) than the other cardiac markers and better specificities (88.2% and 81.7%) than myoglobin at admission and 2 h after admission. Both sensitivity and negative predictive value increased to over 90.0% at 2 h after admission. The areas under the receiver operator characteristic curve for the combination of H-FABP with cTnI were the greatest at admission [0.834 (95% CI: 0.774-0.894)].

引用

页码：342 / 352

页数：11

共 17 条

[1] Do we need additional markers of myocyte necrosis: the potential value of heart fatty-acid-binding protein [J].

Alhadi, HA ;

Fox, KAA .

QJM-AN INTERNATIONAL JOURNAL OF MEDICINE, 2004, 97 (04) :187-198

[2] Diagnostic accuracy of a bedside qualitative immunochromatographic test for acute myocardial infarction [J].

Alhashemi, JA .

AMERICAN JOURNAL OF EMERGENCY MEDICINE, 2006, 24 (02) :149-155

[3] Myocardial infarction redefined -: A consensus Document of the Joint European Society of Cardiology/American College of Cardiology Committee for the Redefinition of Myocardial Infarction [J].

Alpert, JS ;

Antman, E ;

Apple, F ;

Armstrong, PW ;

Bassand, JP ;

de Luna, AB ;

Beller, G ;

Breithardt, G ;

Chaitman, BR ;

Clemmensen, P ;

Falk, E ;

Fishbein, MC ;

Galvani, M ;

Garson, A ;

Grines, C ;

Hamm, C ;

Jaffe, A ;

Katus, H ;

Kjekshus, J ;

Klein, W ;

Klootwijk, P ;

Lenfant, C ;

Levy, D ;

Levy, RI ;

Luepker, R ;

Marcus, F ;

Näslund, U ;

Ohman, M ;

Pahlm, O ;

Poole-Wilson, P ;

Popp, R ;

Alto, P ;

Pyörälä, K ;

Ravkilde, J ;

Rehnquist, N ;

Roberts, W ;

Roberts, R ;

Roelandt, J ;

Rydén, L ;

Sans, S ;

Simoons, ML ;

Thygesen, K ;

Tunstall-Pedoe, H ;

Underwood, R ;

Uretsky, BF ;

Van de Werf, F ;

Voipio-Pulkki, LM ;

Wagner, G ;

Wallentin, L ;

Wijns, W .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2000, 36 (03) :959-969

[4]

Chan C.P.-y., 2006, IVD TECHNOLOGY, V3, P51

[5] Rapid analysis of fatty acid-binding proteins with immunosensors and immunotests for early monitoring of tissue injury [J].

Chan, CPY ;

Wan, TSM ;

Watkins, KL ;

Pelsers, MMAL ;

Van der Voort, DL ;

Tang, FPW ;

Lam, KHK ;

Mill, J ;

Yuan, Y ;

Lehmann, M ;

Hempel, A ;

Sanderson, JE ;

Glatz, JFC ;

Renneberg, R .

BIOSENSORS & BIOELECTRONICS, 2005, 20 (12) :2566-2580

[6]

Chan CPY, 2004, Z KARDIOL, V93, P388, DOI 10.1007/s00392-004-0080-6

[7] Development of a quantitative lateral-flow assay for rapid detection of fatty acid-binding protein [J].

Chan, CPY ;

Sum, KW ;

Cheung, KY ;

Glatz, JFC ;

Sanderson, JE ;

Hempel, A ;

Lehmann, M ;

Renneberg, I ;

Renneberg, R .

JOURNAL OF IMMUNOLOGICAL METHODS, 2003, 279 (1-2) :91-100

[8] Early diagnosis of acute myocardial infarction using immunosensors and immunotests [J].

Chan, CPY ;

Cheng, WS ;

Glatz, JFC ;

van der Voort, D ;

Sanderson, JE ;

Hempel, A ;

Lehmann, M ;

Renneberg, I ;

Renneberg, R .

ANALYTICAL LETTERS, 2003, 36 (09) :1987-2004

[9] Acute chest pain - a stepwise approach, the challenge of the correct clinical diagnosis [J].

Domanovits, H ;

Schillinger, M ;

Paulis, M ;

Rauscha, F ;

Thoennissen, J ;

Nikfardjam, M ;

Laggner, AN .

RESUSCITATION, 2002, 55 (01) :9-16

[10] Pre-hospital detection of acute myocardial infarction with ultra-rapid human fatty acid-binding protein (H-FABP) immunoassay [J].

Ecollan, Patrick ;

Collet, Jean-Philippe ;

Boon, Guillaume ;

Tanguy, Marie-Laure ;

Fievet, Marie-Laurence ;

Haas, Rosita ;

Bertho, Nicolas ;

Siami, Shidash ;

Hubert, Jean-Christophe ;

Coriat, Pierre ;

Montalescot, Gilles .

INTERNATIONAL JOURNAL OF CARDIOLOGY, 2007, 119 (03) :349-354

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