Optimizing immunotherapy for colorectal cancer

被引：74

作者：

Ganesh, Karuna ^{[1
,2
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Mem Hosp, Sloan Kettering Inst, Mol Pharmacol Program, 1275 York Ave, New York, NY 10021 USA

[2] Mem Sloan Kettering Canc Ctr, Mem Hosp, Gastrointestinal Oncol Serv, 1275 York Ave, New York, NY 10021 USA

来源：

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY | 2022年 / 19卷 / 02期

关键词：

NIVOLUMAB;

D O I：

10.1038/s41575-021-00569-4

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Key advances Pembrolizumab (an anti-PD1 monoclonal antibody) has been established as the new standard of care for first-line treatment of metastatic microsatellite-high-mismatch repair-deficient colorectal cancer4. Comprehensive single-cell and spatial analyses of patient samples have identified distinct multicellular immune modulatory hubs in mismatch repair-deficient and mismatch repair-proficient primary colon tumours9. High-fat diet can cause microbiome-dependent downregulation of MHC class II expression on LGR5+ intestinal stem cells in mice, in turn enabling immune evasion and promoting intestinal tumorigenesis10. Important colorectal cancer (CRC) studies in 2021, including a new standard of care for first-line treatment of MSI-H-dMMR metastatic CRC, single-cell and spatial analysis of primary tumours and investigations of diet in preclinical models of cancer initiation, have provided novel insights into the CRC immune microenvironment.

引用

页码：93 / 94

页数：2

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