T-cell costimulation

被引:0
作者
Hutloff, A. [1 ]
机构
[1] Deutsch Rheuma Forschungszentrum Berlin DRFZ, D-10117 Berlin, Germany
来源
ZEITSCHRIFT FUR RHEUMATOLOGIE | 2011年 / 70卷 / 07期
关键词
T-lymphocytes; Autoimmunity; CD28; TIGIT; VISTA; CD226;
D O I
10.1007/s00393-011-0862-y
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Recent publications regarding the function of the T-cell costimulators CD226 and TIGIT as well as the identification of the new costimulatory ligand VISTA are of great interest for an understanding of autoimmune diseases. Both systems display striking similarities to the well-established costimulators CD28/CTLA-4 and PD-1.
引用
收藏
页码:588 / 591
页数:4
相关论文
共 11 条
[1]   CD226 is specifically expressed on the surface of Th1 cells and regulates their expansion and effector functions [J].
Dardalhon, V ;
Schubart, AS ;
Reddy, J ;
Meyers, JH ;
Monney, L ;
Sabatos, CA ;
Ahuja, R ;
Nguyen, K ;
Freeman, GJ ;
Greenfield, EA ;
Sobel, RA ;
Kuchroo, VK .
JOURNAL OF IMMUNOLOGY, 2005, 175 (03) :1558-1565
[2]   Association of the CD226 Ser307 Variant With Systemic Sclerosis Evidence of a Contribution of Costimulation Pathways in Systemic Sclerosis Pathogenesis [J].
Dieude, P. ;
Guedj, M. ;
Truchetet, M. E. ;
Wipff, J. ;
Revillod, L. ;
Riemekasten, G. ;
Matucci-Cerinic, M. ;
Melchers, I. ;
Hachulla, E. ;
Airo, P. ;
Diot, E. ;
Hunzelmann, N. ;
Mouthon, L. ;
Cabane, J. ;
Cracowski, J. L. ;
Riccieri, V. ;
Distler, J. ;
Amoura, Z. ;
Valentini, G. ;
Camaraschi, P. ;
Tarner, I. ;
Frances, C. ;
Carpentier, P. ;
Brembilla, N. C. ;
Meyer, O. ;
Kahan, A. ;
Chizzolini, C. ;
Boileau, C. ;
Allanore, Y. .
ARTHRITIS AND RHEUMATISM, 2011, 63 (04) :1097-1105
[3]   The PD-1 pathway in tolerance and autoimmunity [J].
Francisco, Loise M. ;
Sage, Peter T. ;
Sharpe, Arlene H. .
IMMUNOLOGICAL REVIEWS, 2010, 236 :219-242
[4]   CD226 Gly307Ser association with multiple autoimmune diseases [J].
Hafler, J. P. ;
Maier, L. M. ;
Cooper, J. D. ;
Plagnol, V. ;
Hinks, A. ;
Simmonds, M. J. ;
Stevens, H. E. ;
Walker, N. M. ;
Healy, B. ;
Howson, J. M. M. ;
Maisuria, M. ;
Duley, S. ;
Coleman, G. ;
Gough, S. C. L. ;
Worthington, J. ;
Kuchroo, V. K. ;
Wicker, L. S. ;
Todd, J. A. .
GENES AND IMMUNITY, 2009, 10 (01) :5-10
[5]   Cutting Edge: TIGIT Has T Cell-Intrinsic Inhibitory Functions [J].
Joller, Nicole ;
Hafler, Jason P. ;
Brynedal, Boel ;
Kassam, Nasim ;
Spoerl, Silvia ;
Levin, Steven D. ;
Sharpe, Arlene H. ;
Kuchroo, Vijay K. .
JOURNAL OF IMMUNOLOGY, 2011, 186 (03) :1338-1342
[6]   Vstm3 is a member of the CD28 family and an important modulator of T-cell function [J].
Levin, Steven D. ;
Taft, David W. ;
Brandt, Cameron S. ;
Bucher, Christoph ;
Howard, Edward D. ;
Chadwick, Eric M. ;
Johnston, Janet ;
Hammond, Angela ;
Bontadelli, Kristen ;
Ardourel, Daniel ;
Hebb, LuAnn ;
Wolf, Anitra ;
Bukowski, Thomas R. ;
Rixon, Mark W. ;
Kuijper, Joseph L. ;
Ostrander, Craig D. ;
West, James W. ;
Bilsborough, Janine ;
Fox, Brian ;
Gao, Zeren ;
Xu, Wenfeng ;
Ramsdell, Fred ;
Blazar, Bruce R. ;
Lewis, Katherine E. .
EUROPEAN JOURNAL OF IMMUNOLOGY, 2011, 41 (04) :902-915
[7]   Trans-Endocytosis of CD80 and CD86: A Molecular Basis for the Cell-Extrinsic Function of CTLA-4 [J].
Qureshi, Omar S. ;
Zheng, Yong ;
Nakamura, Kyoko ;
Attridge, Kesley ;
Manzotti, Claire ;
Schmidt, Emily M. ;
Baker, Jennifer ;
Jeffery, Louisa E. ;
Kaur, Satdip ;
Briggs, Zoe ;
Hou, Tie Z. ;
Futter, Clare E. ;
Anderson, Graham ;
Walker, Lucy S. K. ;
Sansom, David M. .
SCIENCE, 2011, 332 (6029) :600-603
[8]   The reverse stop-signal model for CTLA4 function [J].
Rudd, Christopher E. .
NATURE REVIEWS IMMUNOLOGY, 2008, 8 (02) :153-160
[9]   DNAM-1, a novel adhesion molecule involved in the cytolytic function of T lymphocytes [J].
Shibuya, A ;
Campbell, D ;
Hannum, C ;
Yssel, H ;
FranzBacon, K ;
McClanahan, T ;
Kitamura, T ;
Nicholl, J ;
Sutherland, GR ;
Lanier, LL ;
Phillips, JH .
IMMUNITY, 1996, 4 (06) :573-581
[10]   VISTA, a novel mouse Ig superfamily ligand that negatively regulates T cell responses [J].
Wang, Li ;
Rubinstein, Rotem ;
Lines, Janet L. ;
Wasiuk, Anna ;
Ahonen, Cory ;
Guo, Yanxia ;
Lu, Li-Fan ;
Gondek, David ;
Wang, Yan ;
Fava, Roy A. ;
Fiser, Andras ;
Almo, Steve ;
Noelle, Randolph J. .
JOURNAL OF EXPERIMENTAL MEDICINE, 2011, 208 (03) :577-592