Effect of Mineral-Balanced Deep-Sea Water on Kidney Function and Renal Oxidative Stress Markers in Rats Fed a High-Salt Diet

被引：7
作者：
Jo, So Min [1 ]
Nam, Jain [1 ]
Park, Soo-yeon [2 ]
Park, Geonhee [3 ]
Kim, Byeong Goo [3 ]
Jeong, Gwi-Hwa [3 ]
Hurh, Byung Serk [3 ]
Kim, Ji Yeon [1 ,2 ]
机构：
[1] Seoul Natl Univ Sci & Technol, Dept Food Sci & Technol, Seoul 01811, South Korea
[2] Seoul Natl Univ Sci & Technol, Dept Nano Bio Engn, Seoul 01811, South Korea
[3] Sempio Fermentat Res Ctr, 183 Osongsaengmyeong,4 Ro, Cheongju 28156, Chungcheongbuk, South Korea
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 24期
基金：
新加坡国家研究基金会;
关键词：
deep sea water; kidney; high-salt diet; antioxidant; kidney injury; sodium excretion; magnesium; calcium; RNA-seq; BLOOD-PRESSURE; NAD(P)H OXIDASE; MAGNESIUM; HYPERTENSION; ALDOSTERONE; MEGALIN; CALCIUM; MICE; SUPPLEMENTATION; DYSFUNCTION;
D O I：
10.3390/ijms222413415
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
This study investigated the effect of mineral-balanced deep-sea water (DSW) on kidney health using an animal model of kidney injury due to a high-sodium diet. High magnesium/low sodium (HMLS) and high magnesium/high calcium (HMHC) DSW samples with different mineral contents were prepared. Sprague-Dawley rats were fed an 8% sodium chloride (NaCl) diet for four weeks to induce kidney injury, and each group was supplied with purified water or mineral water. Kidney injury was observed in the NaCl group according to increased kidney injury markers and malondialdehydes, providing evidence of oxidative stress. However, the kidney injury was repaired by the intake of mineral-balanced DSW. It was confirmed that the HMLS and HMHC groups showed improved Na+ excretion through the urine. Kidney injury markers in urine decreased and upregulation of low-density lipoprotein receptor-related protein2 mRNA expression was observed in the HMLS and HMHC groups. In addition, superoxide dismutase activity was increased in the HMHC groups. The gene expression patterns of the RNA sequencing were similar between the CON and HMLS groups. These results suggest that DSW has beneficial effects on kidney health due to the balanced magnesium and calcium levels in models of kidney injury caused by excessive sodium intake.
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页数：16
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共 51 条
[1]   STUDY OF ANTIOXIDANT PROPERTIES OF METAL ASPARTATES [J].
AFANASEV, IB ;
SUSLOVA, TB ;
CHEREMISINA, ZP ;
ABRAMOVA, NE ;
KORKINA, LG .
ANALYST, 1995, 120 (03) :859-862
[2]   Angiotensinogen as a biomarker of acute kidney injury [J].
Aqeel, Sheeba Habeeb Ba ;
Sanchez, Alejandro ;
Batlle, Daniel .
CLINICAL KIDNEY JOURNAL, 2017, 10 (06) :759-768
[3]  
BERTHELOT A, 1983, J AM COLL NUTR, V2, P343
[4]   Renal Control of Calcium, Phosphate, and Magnesium Homeostasis [J].
Blaine, Judith ;
Chonchol, Michel ;
Levi, Moshe .
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2015, 10 (07) :1257-1272
[5]   NPHS2, encoding the glomerular protein podocin, is mutated in autosomal recessive steroid-resistant nephrotic syndrome [J].
Boute, N ;
Gribouval, O ;
Roselli, S ;
Benessy, F ;
Lee, H ;
Fuchshuber, A ;
Dahan, K ;
Gubler, MC ;
Niaudet, P ;
Antignac, C .
NATURE GENETICS, 2000, 24 (04) :349-354
[6]   Aldosterone: effects on the kidney and cardiovascular system [J].
Briet, Marie ;
Schiffrin, Ernesto L. .
NATURE REVIEWS NEPHROLOGY, 2010, 6 (05) :261-273
[7]   Increased phagocytosis and production of reactive oxygen species by neutrophils during magnesium deficiency in rats and inhibition by high magnesium concentration [J].
Bussière, FI ;
Gueux, E ;
Rock, E ;
Girardeau, JP ;
Tridon, A ;
Mazur, A ;
Rayssiguier, Y .
BRITISH JOURNAL OF NUTRITION, 2002, 87 (02) :107-113
[8]   Impact of Angiotensin Type 1A Receptors in Principal Cells of the Collecting Duct on Blood Pressure and Hypertension [J].
Chen, Daian ;
Stegbauer, Johannes ;
Sparks, Matthew A. ;
Kohan, Donald ;
Griffiths, Robert ;
Herrera, Marcela ;
Gurley, Susan B. ;
Coffman, Thomas M. .
HYPERTENSION, 2016, 67 (06) :1291-+
[9]   Temporal Trends in Dietary Sodium Intake Among Adults Aged ≥19 Years - United States, 2003-2016 [J].
Clarke, Lasha S. ;
Overwyk, Katherine ;
Bates, Marlana ;
Park, Soyoun ;
Gillespie, Cathleen ;
Cogswell, Mary E. .
MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT, 2021, 70 (42) :1478-1482
[10]   Kidney in hypertension - Guyton redux [J].
Coffman, Thomas M. ;
Crowley, Steven D. .
HYPERTENSION, 2008, 51 (04) :811-816
123456