Low Relative Abundances of the Mucolytic Bacterium Akkermansia muciniphila and Bifidobacterium spp. in Feces of Children with Autism

被引：334
作者：
Wang, Lv [1 ]
Christophersen, Claus T. [2 ]
Sorich, Michael J. [1 ]
Gerber, Jacobus P. [1 ]
Angley, Manya T. [1 ]
Conlon, Michael A. [2 ]
机构：
[1] Univ S Australia, Sansom Inst Hlth Res, Adelaide, SA 5001, Australia
[2] CSIRO Food & Nutrit Sci, Adelaide, SA 5001, Australia
来源：
APPLIED AND ENVIRONMENTAL MICROBIOLOGY | 2011年 / 77卷 / 18期
关键词：
SPECTRUM DISORDERS; MICROFLORA; BARRIER; MUCIN; ACID;
D O I：
10.1128/AEM.05212-11
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Gastrointestinal disturbance is frequently reported for individuals with autism. We used quantitative real-time PCR analysis to quantify fecal bacteria that could influence gastrointestinal health in children with and without autism. Lower relative abundances of Bifidobacteria species and the mucolytic bacterium Akkermansia muciniphila were found in children with autism, the latter suggesting mucus barrier changes.
引用
收藏
页码：6718 / 6721
页数：4
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