Combinatorial chemistry and natural products. Teicoplanin aglycone as a molecular scaffold for solid phase synthesis of combinatorial libraries

被引：16

作者：

Seneci, P ^{[1
]}

Sizemore, C ^{[1
]}

Islam, K ^{[1
]}

Kocis, P ^{[1
]}

机构：

[1] HOECHST MARION ROUSSEL,SELECTICIDE CORP,TUCSON,AZ 85737

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 35期

关键词：

D O I：

10.1016/0040-4039(96)01350-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Teicoplanin aglycone 1 has been linked to a solid support via two different double cleavable linkers. The attachment was realized selectively on the (COOH)-C-38 function of 1. Two molecules of 1 were attached on each linker moiety and could be separately released with different mechanisms. The release properties of the resin bound entities were determined by means of analytical and biological characterization. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：6319 / 6322

页数：4

共 13 条

[1] THE STRUCTURE AND MODE OF ACTION OF GLYCOPEPTIDE ANTIBIOTICS OF THE VANCOMYCIN GROUP [J].

BARNA, JCJ ;

WILLIAMS, DH .

ANNUAL REVIEW OF MICROBIOLOGY, 1984, 38 :339-357

[2] TEICHOMYCINS, NEW ANTIBIOTICS FROM ACTINOPLANES-TEICHOMYCETICUS NOV-SP .4. SEPARATION AND CHARACTERIZATION OF THE COMPONENTS OF TEICHOMYCIN (TEICOPLANIN) [J].

BORGHI, A ;

CORONELLI, C ;

FANIUOLO, L ;

ALLIEVI, G ;

PALLANZA, R ;

GALLO, GG .

JOURNAL OF ANTIBIOTICS, 1984, 37 (06) :615-620

[3] PEPTIDOSTEROIDAL RECEPTORS FOR OPIOID-PEPTIDES - SEQUENCE-SELECTIVE BINDING USING A SYNTHETIC RECEPTOR LIBRARY [J].

BOYCE, R ;

LI, G ;

NESTLER, HP ;

SUENAGA, T ;

STILL, WC .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1994, 116 (17) :7955-7956

[4]

EICHLER J, 1995, MOL MED TODAY, P174

[5] SYMMETRICAL STRUCTURE ALLOWING THE SELECTIVE MULTIPLE RELEASE OF A DEFINED QUANTITY OF PEPTIDE FROM A SINGLE BEAD OF POLYMERIC SUPPORT [J].

KOCIS, P ;

KRCHNAK, V ;

LEBL, M .

TETRAHEDRON LETTERS, 1993, 34 (45) :7251-7252

[6] ONE-BEAD ONE-STRUCTURE COMBINATORIAL LIBRARIES [J].

LEBL, M ;

KRCHNAK, V ;

SEPETOV, NF ;

SELIGMANN, B ;

STROP, P ;

FELDER, S ;

LAM, KS .

BIOPOLYMERS, 1995, 37 (03) :177-198

[7] TEICOPLANIN, ANTIBIOTICS FROM ACTINOPLANES-TEICHOMYCETICUS NOV-SP .7. PREPARATION AND NMR CHARACTERISTICS OF THE AGLYCONE OF TEICOPLANIN [J].

MALABARBA, A ;

FERRARI, P ;

GALLO, GG ;

KETTENRING, J ;

CAVALLERI, B .

JOURNAL OF ANTIBIOTICS, 1986, 39 (10) :1430-1442

[8] OCTAPEPTIDE DERIVATIVES OF TEICOPLANIN ANTIBIOTICS [J].

MALABARBA, A ;

CIABATTI, R ;

SCOTTI, R ;

GOLDSTEIN, BP .

JOURNAL OF ANTIBIOTICS, 1993, 46 (04) :661-667

[9] N63-CARBOXAMIDES OF N-15-ALKYL AND N15,N15-DIALKYL DERIVATIVES OF TEICOPLANIN AND DEGLUCOTEICOPLANIN [J].

MALABARBA, A ;

CIABATTI, R ;

KETTENRING, J ;

SCOTTI, R ;

CANDIANI, G ;

BERTI, M ;

PALLANZA, R ;

GOLDSTEIN, BP .

JOURNAL OF ANTIBIOTICS, 1993, 46 (04) :668-675

[10] DISCOVERY OF BIOLOGICALLY-ACTIVE PEPTIDES IN RANDOM LIBRARIES - SOLUTION-PHASE TESTING AFTER STAGED ORTHOGONAL RELEASE FROM RESIN BEADS [J].

SALMON, SE ;

LAM, KS ;

LEBL, M ;

KANDOLA, A ;

KHATTRI, PS ;

WADE, S ;

PATEK, M ;

KOCIS, P ;

KRCHNAK, V ;

THORPE, D ;

FELDER, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (24) :11708-11712

← 1 2 →