Characterization of unrelated clinical Legionella pneumophila isolates in Catalonia by monoclonal subgrouping and sequence-based typing

被引：5

作者：

Garcia-Nunez, Marian ^{[1
,2
,3
]}

Quero, Sara ^{[1
,2
,3
]}

Lluisa Pedro-Botet, Maria ^{[1
,2
,3
]}

Barrabeig, Irene ^{[4
]}

Avarez, Josep ^{[4
]}

Campoy, Irene ^{[1
]}

Rosa Sala, Maria ^{[4
]}

Parraga-Nino, Noemi ^{[1
,2
,3
]}

Minguell, Sofia ^{[4
]}

Cayla, Joan ^{[4
,5
]}

Mateu, Lourdes ^{[1
,2
,3
]}

Sabria, Miquel ^{[1
,2
,3
]}

机构：

[1] Hosp Badalona Germans Trias & Pujol, Fundacio Inst Invest Germans Trias & Pujol, Infect Dis Unit, E-08916 Badalona, Spain

[2] Autonomous Univ Barcelona, Grp Estudio Legionelosis, E-08913 Cerdanyola Del Valles, Spain

[3] Ciber Enfermedades Resp, E-28029 Madrid, Spain

[4] Publich Hlth Agcy Catalonia, Epidemiol Surveillance, E-08005 Barcelona, Spain

[5] Ciber Salud Publ, E-28029 Madrid, Spain

来源：

FUTURE MICROBIOLOGY | 2016年 / 11卷 / 07期

关键词：

clinical isolates; Legionella; monoclonal antibody; sequence-based typing; COMMUNITY-ACQUIRED PNEUMONIA; LEGIONNAIRES-DISEASE; ANTIBODY SUBGROUPS; COOLING-TOWER; SEROGROUPS; LIPOPOLYSACCHARIDE; OUTBREAK; JAPAN; WATER; PERSISTENCE;

D O I：

10.2217/fmb-2016-0013

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Aim: To characterize the genetic diversity of unrelated Legionella pneumophila clinical isolates in Catalonia and compare with other European regions. Methods: 95 unrelated isolates were analyzed using monoclonal antibodies and sequence-based typing, 1989-2013. Results: The isolates showed a high diversity (IOD 0.964) with a predominance of some profiles (ST37-Phialdelphia, ST23-Philadelphia and ST1-OLDA). All regions had predominant sequence types (STs) that differed between regions, and only 3% of STs were shared between the three regions. Conclusion: L. pneumophila clinical isolates from Catalonia presented a high diversity and can be used in epidemiological surveillance studies. The heterogeneous predominance of STs between European regions suggested a relationship between geographical distribution and virulence of some STs.

引用

页码：865 / 875

页数：11

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