Cytoplasmic intermediate filaments mediate actin-driven positioning of the nucleus

被引：87

作者：

Dupin, Isabelle

Sakamoto, Yasuhisa

Etienne-Manneville, Sandrine ^{[1
]}

机构：

[1] Inst Pasteur, Cell Polar & Migrat Grp, F-75724 Paris 15, France

来源：

JOURNAL OF CELL SCIENCE | 2011年 / 124卷 / 06期

关键词：

Actin; Intermediate filament; Micropattern; Migration; Nucleus; MTOC POLARIZATION; ENVELOPE; VIMENTIN; NESTIN; CDC42; MIGRATION; MOVEMENT; PROTEIN; NUCLEOKINESIS; EXPRESSION;

D O I：

10.1242/jcs.076356

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The localization of the nucleus is precisely regulated, and defects in nuclear positioning are observed in diseases such as lissencephaly, cerebellar ataxia and dysplasia. We show here that cytoplasmic intermediate filaments are essential players in actin-dependent positioning of the nucleus. The actin retrograde flow is relayed by a flow of intermediate filaments that accumulate asymmetrically around the nuclear envelope. Perturbations of the intermediate filament network alter positioning of the nucleus in both migrating and immobile astrocytes. This function of intermediate filaments might be crucial for regulating cell motility, in particular in tumor cells expressing high levels of cytoplasmic intermediate filaments.

引用

页码：865 / 872

页数：8

共 38 条

[1] Nucleokinesis in tangentially migrating neurons comprises two alternating phases:: Forward migration of the Golgi/centrosome associated with centrosome splitting and myosin contraction at the rear [J].