T cell receptor (TCR) signaling in health and disease

被引：304

作者：

Shah, Kinjal ^{[1
,2
]}

Al-Haidari, Amr ^{[3
,4
]}

Sun, Jianmin ^{[1
,2
,5
]}

Kazi, Julhash U. ^{[1
,2
]}

机构：

[1] Lund Univ, Dept Lab Med, Div Translat Canc Res, Lund, Sweden

[2] Lund Univ, Dept Lab Med, Lund Stem Cell Ctr, Lund, Sweden

[3] Skane Univ Hosp, Clin Genet & Pathol, Lund, Region Skane, Sweden

[4] Lund Univ, Surg Res Unit, Clin Sci Dept, Malmo, Sweden

[5] Ningxia Med Univ, Sch Basic Med Sci, Ctr Sci & Technol, NHC Key Lab Metab Cardiovasc Dis Res, Yinchuan, Ningxia, Peoples R China

来源：

SIGNAL TRANSDUCTION AND TARGETED THERAPY | 2021年 / 6卷 / 01期

关键词：

PROTEIN-TYROSINE KINASE; NF-KAPPA-B; LINKED LYMPHOPROLIFERATIVE-DISEASE; TRANSMEMBRANE ADAPTER PROTEIN; SEVERE COMBINED IMMUNODEFICIENCY; NUCLEOTIDE-RELEASING PROTEIN; TERMINAL SRC KINASE; HOMOLOGY; DOMAIN; ANTIGEN-RECEPTOR; ALPHA-BETA;

D O I：

10.1038/s41392-021-00823-w

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Interaction of the T cell receptor (TCR) with an MHC-antigenic peptide complex results in changes at the molecular and cellular levels in T cells. The outside environmental cues are translated into various signal transduction pathways within the cell, which mediate the activation of various genes with the help of specific transcription factors. These signaling networks propagate with the help of various effector enzymes, such as kinases, phosphatases, and phospholipases. Integration of these disparate signal transduction pathways is done with the help of adaptor proteins that are non-enzymatic in function and that serve as a scaffold for various protein-protein interactions. This process aids in connecting the proximal to distal signaling pathways, thereby contributing to the full activation of T cells. This review provides a comprehensive snapshot of the various molecules involved in regulating T cell receptor signaling, covering both enzymes and adaptors, and will discuss their role in human disease.

引用

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