Molecular Biology and Evolution of Cancer: From Discovery to Action

被引：42

作者：

Somarelli, Jason A. ^{[1
,2
]}

Gardner, Heather ^{[3
]}

Cannataro, Vincent L. ^{[4
]}

Gunady, Ella F. ^{[1
]}

Boddy, Amy M. ^{[5
]}

Johnson, Norman A. ^{[6
]}

Fisk, Jeffrey Nicholas ^{[7
]}

Gaffney, Stephen G. ^{[7
]}

Chuang, Jeffrey H. ^{[8
]}

Li, Sheng ^{[8
]}

Ciccarelli, Francesca D. ^{[9
,10
]}

Panchenko, Anna R. ^{[11
,12
]}

Megquier, Kate ^{[13
,14
]}

Kumar, Sudhir ^{[15
,16
]}

Dornburg, Alex ^{[17
]}

DeGregori, James ^{[18
]}

Townsend, Jeffrey P. ^{[7
,19
,20
]}

机构：

[1] Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA

[2] Duke Univ, Med Ctr, Duke Canc Inst, Durham, NC USA

[3] Tufts Univ, Sackler Sch Grad Biomed Sci, Medford, MA 02155 USA

[4] Emmanuel Coll, Dept Biol, Boston, MA USA

[5] Univ Calif Santa Barbara, Dept Anthropol, Santa Barbara, CA 93106 USA

[6] Univ Massachusetts, Dept Biol, Amherst, MA 01003 USA

[7] Yale Sch Publ Hlth, Dept Biostat, New Haven, CT 06510 USA

[8] Jackson Lab Genom Med, Farmington, CT USA

[9] Francis Crick Inst, Canc Syst Biol Lab, London, England

[10] Kings Coll London, London, England

[11] Queens Univ, Sch Med, Dept Pathol & Mol Med, Kingston, ON, Canada

[12] Ontario Inst Canc Res, Toronto, ON, Canada

[13] MIT, Broad Inst, 77 Massachusetts Ave, Cambridge, MA 02139 USA

[14] Harvard Univ, Cambridge, MA 02138 USA

[15] Temple Univ, Inst Genom & Evolutionary Med, Philadelphia, PA 19122 USA

[16] Temple Univ, Dept Biol, Philadelphia, PA 19122 USA

[17] North Carolina Museum Nat Sci, Raleigh, NC USA

[18] Univ Colorado, Dept Biochem & Mol Genet, Anschutz Med Campus, Aurora, CO USA

[19] Yale Univ, Dept Ecol & Evolutionary Biol, New Haven, CT 06520 USA

[20] Yale Univ, Program Computat Biol & Bioinformat, New Haven, CT 06520 USA

来源：

MOLECULAR BIOLOGY AND EVOLUTION | 2020年 / 37卷 / 02期

基金：

美国国家卫生研究院;

关键词：

cancer; fitness landscapes; metastasis; genomics; tumor phylogenetics; comparative oncology; COPY-NUMBER ALTERATIONS; CELL-CYCLE; LINEAGE PLASTICITY; TUMOR EVOLUTION; RESISTANCE; HETEROGENEITY; METASTASIS; PROMOTES; CONTRIBUTES; MUTATIONS;

D O I：

10.1093/molbev/msz242

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cancer progression is an evolutionary process. During this process, evolving cancer cell populations encounter restrictive ecological niches within the body, such as the primary tumor, circulatory system, and diverse metastatic sites. Efforts to prevent or delay cancer evolution-and progression-require a deep understanding of the underlying molecular evolutionary processes. Herein we discuss a suite of concepts and tools from evolutionary and ecological theory that can inform cancer biology in new and meaningful ways. We also highlight current challenges to applying these concepts, and propose ways in which incorporating these concepts could identify new therapeutic modes and vulnerabilities in cancer.

引用

页码：320 / 326

页数：7

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