Low Bone Mineral Density in Young Patients Newly Diagnosed with Inflammatory Bowel Disease

被引：8

作者：

Lee, Joon Seop ^{[1
]}

Lee, Hyun Seok ^{[1
]}

Jang, Byung Ik ^{[2
]}

Kim, Eun Soo ^{[1
]}

Kim, Sung Kook ^{[1
]}

Kim, Kyeong Ok ^{[2
]}

Lee, Yoo Jin ^{[3
]}

Lee, Hyun Jik ^{[3
]}

Kim, Eun Young ^{[4
]}

Lung, Yun Jin ^{[5
]}

Yang, Chang Heon ^{[6
]}

机构：

[1] Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, 807 Hokuk Ro, Daegu 41404, South Korea

[2] Yeungnam Univ, Dept Internal Med, Coll Med, Daegu, South Korea

[3] Keimyung Univ, Dept Internal Med, Sch Med, Daegu, South Korea

[4] Catholic Univ Daegu, Dept Internal Med, Sch Med, Daegu, South Korea

[5] Fatima Hosp Daegu, Dept Internal Med, Daegu, South Korea

[6] Dongguk Univ, Dept Internal Med, Sch Med, Gyeongju, South Korea

来源：

DIGESTIVE DISEASES AND SCIENCES | 2021年 / 66卷 / 02期

关键词：

Inflammatory bowel disease; Bone mineral density; Ulcerative colitis; Crohn's disease; FRACTURE RISK; CROHNS-DISEASE; OSTEOPOROSIS; PREVALENCE;

D O I：

10.1007/s10620-020-06220-7

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background The prevalence and risk factors of low bone mineral density (BMD) in Asian patients newly diagnosed with inflammatory bowel disease (IBD) have not been fully suggested. Aims We aimed to examine the prevalence and risk factors of low BMD in young Korean patients newly diagnosed with IBD. Methods We prospectively enrolled 132 patients aged less than 50 years and newly diagnosed with IBD from six tertiary referral centers in Korea between November 2014 and April 2017. BMD was measured by dual-energy X-ray absorptiometry, and then the Z-score was determined. We defined low BMD as a Z-score <= - 1.0. Results Of 68 patients with ulcerative colitis (UC), 22 (32.4%) had low BMD. Also, of 64 patients with Crohn's disease (CD), 24 (37.5%) showed low BMD. Results from multivariate regression analysis identified the risk factors for low BMD as a high level of alkaline phosphatase (ALP) (>= 140 U/L) (P = 0.010) in UC patients, and being underweight (body mass index <= 18.5 kg/m(2)) (P = 0.017) in CD patients. Conclusions Our study showed that about one-third of newly diagnosed IBD Asian patients had low BMD. The clinical factors associated with low BMD were a high level of ALP in UC patients, and being underweight, in CD patients. Therefore, measurements of BMD in young patients should be considered at the diagnosis of IBD.

引用

页码：605 / 611

页数：7

共 25 条

[1] METABOLIC BONE ASSESSMENT IN PATIENTS WITH INFLAMMATORY BOWEL-DISEASE [J].