The role of ferroptosis in endothelial cell dysfunction

被引：15

作者：

Yuan, Wei ^{[1
]}

Xia, Hao ^{[1
]}

Xu, Yao ^{[1
]}

Xu, Chong ^{[1
]}

Chen, Nan ^{[1
]}

Shao, Chen ^{[1
]}

Dai, Zhiyin ^{[1
]}

Chen, Rui ^{[1
]}

Tao, Aibin ^{[2
]}

机构：

[1] Jiangsu Univ, Affiliated Hosp, Dept Cardiol, Zhenjiang, Jiangsu, Peoples R China

[2] Jiangsu Univ, Affiliated Peoples Hosp, Dept Cardiol, Zhenjiang, Jiangsu, Peoples R China

来源：

CELL CYCLE | 2022年 / 21卷 / 18期

关键词：

endothelial cell; ferroptosis; endothelial cell dysfunction; ROS; iron; INTIMA-MEDIA THICKNESS; LIPID-PEROXIDATION; IRON-METABOLISM; MECHANISMS; HEMORRHAGE; SEPSIS; ATHEROSCLEROSIS; INFLAMMATION; MACROPHAGES; PROTECTS;

D O I：

10.1080/15384101.2022.2079054

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Ferroptosis is a form of iron-dependent cell death caused by an excessive accumulation of reactive oxygen species and lipid peroxidation. The importance of ferroptosis in the occurrence and progression of various diseases is gradually being recognized; however, the exact biological effects and potential mechanisms of endothelial cell ferroptosis remain unclear. The endothelium forms the innermost layer of the blood vessels and lymphatic vessels. It acts as an important functional interface, responds to various pathological stimuli and causes endothelial dysfunction. Here, we review recent findings to elucidate the role of ferroptosis in endothelial cells under different pathophysiologic settings.

引用

页码：1897 / 1914

页数：18

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