Use of adjuvants in the treatment of Acinetobacter baumannii

被引：4

作者：

Eugenia Pachon-Ibanez, Maria ^{[1
]}

Smani, Younes ^{[1
]}

Pachon, Jeronimo ^{[1
]}

机构：

[1] Univ Seville, Clin Unit Infect Dis Microbiol & Prevent Med, Inst Biomed Seville IBiS, Univ Hosp Virgen del Rocio,CSIC, Seville, Spain

来源：

EXPERT REVIEW OF ANTI-INFECTIVE THERAPY | 2016年 / 14卷 / 02期

关键词：

Acinetobacter baumannii; antimicrobial resistance; adjuvant antibiotics; MULTIDRUG-RESISTANT BACTERIA; INFECTIONS; LYSOPHOSPHATIDYLCHOLINE; EVOLUTION; EFFICACY; OPTIONS; PEPTIDE;

D O I：

10.1586/14787210.2016.1126508

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The current antibiotic crisis to treat infections by Acinetobacter baumannii is linked with the increase of antimicrobial resistance and the lack of development of new antimicrobial drugs. For this reason, new alternatives for the treatment and control of infections by A. baumannii are necessary. Several studies have reported the effect of adjuvants to restore the efficacy of existing antimicrobial agents. Herein, we analyzed the main results on the development of adjuvant drugs, as monotherapy or in combination therapy with existing antimicrobial agents, which have shown promising results in vitro and in vivo. However, caution is needed and further extensive in vivo studies have to be performed to confirm the potential use of these adjuvants as true therapeutic alternatives.

引用

页码：153 / 155

页数：3

共 20 条

[1] Potential Synergy Activity of the Novel Ceragenin, CSA-13, against Carbapenem-Resistant Acinetobacter baumannii Strains Isolated from Bacteremia Patients [J].

Bozkurt-Guzel, Cagla ;

Savage, Paul B. ;

Akcali, Alper ;

Ozbek-Celik, Berna .

BIOMED RESEARCH INTERNATIONAL, 2014, 2014

[2]

Cebrero-Cangueiro T, 2015, 10 INT S BIOL AC 201, P142

[3] Infection Control Programs and Antibiotic Control Programs to Limit Transmission of Multi-Drug Resistant Acinetobacter baumannii Infections: Evolution of Old Problems and New Challenges for Institutes [J].

Chen, Chang-Hua ;

Lin, Li-Chen ;

Chang, Yu-Jun ;

Chen, Yu-Min ;

Chang, Chin-Yen ;

Huang, Chieh-Chen .

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 2015, 12 (08) :8871-8882

[4] Enhancing antibiotic activity: a strategy to control Acinetobacter infections [J].

Chusri, Sasitorn ;

Villanueva, Ivan ;

Voravuthikunchai, Supayang Piyawan ;

Davies, Julian .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2009, 64 (06) :1203-1211

[5] An unusual class of anthracyclines potentiate Gram-positive antibiotics in intrinsically resistant Gram-negative bacteria [J].

Cox, Georgina ;

Koteva, Kalinka ;

Wright, Gerard D. .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2014, 69 (07) :1844-1855

[6] Efficacy of the small molecule inhibitor of Lipid II BAS00127538 against Acinetobacter baumannii [J].

de Leeuw, Erik P. H. .

DRUG DESIGN DEVELOPMENT AND THERAPY, 2014, 8 :1061-1064

[7]

Dellinger RP, 2013, INTENSIVE CARE MED, V39, P165, DOI [10.1007/s00134-012-2769-8, DOI 10.1007/S00134-012-2769-8]

[8] Antimicrobial susceptibility among gram-negative isolates collected in the USA between 2005 and 2011 as part of the Tigecycline Evaluation and Surveillance Trial (TEST) [J].

Denys, Gerald A. ;

Callister, Steven M. ;

Dowzicky, Michael J. .

ANNALS OF CLINICAL MICROBIOLOGY AND ANTIMICROBIALS, 2013, 12

[9] Acinetobacter baumannii: Evolution of Antimicrobial Resistance-Treatment Options [J].

Doi, Yohei ;

Murray, Gerald L. ;

Peleg, Anton Y. .

SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE, 2015, 36 (01) :85-98

[10] In vitro activity of 18 antimicrobial agents against clinical isolates of Acinetobacter spp.: multicenter national study GEIH-REIPI-Ab 2010 [J].

Fernandez-Cuenca, Felipe ;

Tomas-Carmona, Maria ;

Caballero-Moyano, Francisco ;

Bou, German ;

Martinez-Martinez, Luis ;

Vila, Jordi ;

Pachon, Jeronimo ;

Miguel Cisneros, Jose ;

Rodriguez-Bano, Jesus ;

Pascual, Alvaro .

ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA, 2013, 31 (01) :4-9

← 1 2 →