NOP7 interacts with β-catenin and activates β-catenin/TCF signaling in hepatocellular carcinoma cells

被引：7
|
作者：
Wu, Nan [1 ]
Zhao, Jing [2 ,3 ]
Yuan, Youhua [4 ]
Lu, Chuanjia [1 ]
Zhu, Wenjing [1 ]
Jiang, Qun [1 ]
机构：
[1] Fudan Univ, Shanghai Stomatol Hosp, Dept Clin Lab, Shanghai, Peoples R China
[2] Fudan Univ, Huashan Hosp, Dept Gen Surg, Shanghai, Peoples R China
[3] Fudan Univ, Canc Metastasis Inst, Shanghai, Peoples R China
[4] Henan Prov Peoples Hosp, Dept Clin Lab, Zhengzhou, Henan, Peoples R China
来源：
ONCOTARGETS AND THERAPY | 2018年 / 11卷
关键词：
hepatocellular carcinoma; NOP7; beta-catenin/TCF pathway; cell growth; cell migration; BIOGENESIS; YTM1; COMPLEX; GROWTH; AXIN1; ERB1;
D O I：
10.2147/OTT.S164601
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Background: The hyperactivation of beta-catenin signaling is frequently observed in clinical hepatocellular carcinoma (HCC) samples. Further understanding the mechanisms involved in activating beta-catenin/TCF signaling would benefit the treatment of HCC. Method and results: Here, it was found that NOP7 was a binding partner of beta-catenin. NOP7 strengthened the interaction between beta-catenin and TCF4, which led to the activation of beta-catenin/TCF signaling. The upregulation of NOP7 in HCC promoted the growth (in both liquid culture and soft agar) and migration of HCC cancer cells. Conclusion: Taken together, we have demonstrated the oncogenic functions of NOP7 in HCC, suggesting that targeting NOP7 would benefit the treatment of HCC.
引用
收藏
页码：6369 / 6376
页数：8
相关论文
共 50 条
  • [1] CARF activates beta-catenin/TCF signaling in the hepatocellular carcinoma
    Fan, Xin
    Ma, Xiaoyan
    Cui, Lei
    Dang, Shengchun
    Qu, Jianguo
    Zhang, Jianxin
    Wang, Xuqing
    Mao, Zhengfa
    ONCOTARGET, 2016, 7 (49) : 80404 - 80414
  • [2] CDK7 activated beta-catenin/TCF signaling in hepatocellular carcinoma
    Duan, Juan
    He, Yan
    Fu, Xiaolin
    Deng, Yujie
    Zheng, Min
    Lu, Dongdong
    EXPERIMENTAL CELL RESEARCH, 2018, 370 (02) : 461 - 467
  • [3] Regulation of the Wnt/β-catenin signaling pathway in hepatocellular carcinoma cells by TCF-4 isoforms
    Tomimaru, Yoshito
    Wands, Jack R.
    Kim, Miran
    HEPATOLOGY, 2012, 56 : 788A - 789A
  • [4] β-Catenin signaling in hepatocellular carcinoma
    Xu, Chuanrui
    Xu, Zhong
    Zhang, Yi
    Evert, Matthias
    Calvisi, Diego F.
    Chen, Xin
    JOURNAL OF CLINICAL INVESTIGATION, 2022, 132 (04):
  • [5] WNT/β-Catenin Signaling and Hepatocellular Carcinoma
    Wands, Jack R.
    Kim, Miran
    HEPATOLOGY, 2014, 60 (02) : 452 - 454
  • [6] Wnt secretion is not required to sustain Wnt/β-catenin signaling in β-catenin mutant hepatocellular carcinoma cells
    Wang, W.
    EUROPEAN JOURNAL OF CANCER, 2016, 61 : S163 - S163
  • [7] TCF4/β-Catenin Complex Activates Smo and Gli1 to Promote Migration and Proliferation of Hepatocellular Carcinoma Cells
    Feng, R.
    Haitao, J.
    Hui, Su
    Wang, W.
    Chen, Y.
    INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2019, 81 (06) : 1045 - 1052
  • [8] WDR34 Activates Wnt/Beta-Catenin Signaling in Hepatocellular Carcinoma
    Xiaoling Luo
    Yuting Liu
    Shijie Ma
    Lei Liu
    Rui Xie
    Shaochuang Wang
    Digestive Diseases and Sciences, 2019, 64 : 2591 - 2599
  • [9] WDR34 Activates Wnt/Beta-Catenin Signaling in Hepatocellular Carcinoma
    Luo, Xiaoling
    Liu, Yuting
    Ma, Shijie
    Liu, Lei
    Xie, Rui
    Wang, Shaochuang
    DIGESTIVE DISEASES AND SCIENCES, 2019, 64 (09) : 2591 - 2599
  • [10] MIR-431 ACTIVATES WNT/β-CATENIN SIGNALING TO PROMOTE HEPATOCELLULAR CARCINOMA METASTASIS
    Xie, C.
    Wang, P-P.
    Zhang, G-L.
    Wang, K.
    Peng, L.
    Gao, Z-L.
    JOURNAL OF HEPATOLOGY, 2014, 60 (01) : S83 - S83
12345