Endometriosis stem cell sources and potential therapeutic targets: literature review and bioinformatics analysis

被引：3
|
作者：
Jin, Zhe [1 ,2 ]
Zhang, Yize [1 ,2 ]
Li, Jingyi [3 ]
Lv, Sidi [1 ,2 ]
Zhang, Lixia [4 ]
Feng, Ying [1 ]
机构：
[1] Nanchang Univ, Affiliated Hosp 2, Nanchang 330006, Jiangxi, Peoples R China
[2] Nanchang Univ, Clin Med Sch 2, Nanchang 330031, Jiangxi, Peoples R China
[3] Nanchang Univ, Sch Publ Hlth, Nanchang 330031, Jiangxi, Peoples R China
[4] First Hosp Handan City, Handan 056004, Hebei, Peoples R China
来源：
REGENERATIVE MEDICINE | 2021年 / 16卷 / 10期
关键词：
CXCL12/CXCR4; endometriosis; MMPs/TIMPs; stem cells; survivin (BIRC5); therapeutic targets; VEGF/HIF-1; alpha; ENDOTHELIAL GROWTH-FACTOR; PROGENITOR CELLS; STROMAL CELLS; EXPRESSION; MIGRATION; APOPTOSIS; SURVIVIN; WOMEN; PROLIFERATION; ANGIOGENESIS;
D O I：
10.2217/rme-2021-0039
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
The stem cell origin theory of endometriosis (EMS) is a significant area of new research but the sources of this have yet to be adequately summarized. Existing treatments for EMS are commonly associated with a high recurrence rate; consequently, there is an urgent need to develop new therapeutic measures for the future treatment of this disease from the view of stem cells and gene therapy. Recently, we describe the evidence for the potential sources of EMS stem cells and other key molecules participating in the establishment of lesions, and predict the miRNAs that target these key genes via bioinformatics analysis for further research. The review highlights the origin of EMS stem cells and potential therapy targets.
引用
收藏
页码：949 / 962
页数：14
相关论文
共 50 条
  • [41] Integrated Bioinformatics Analysis Reveals Marker Genes and Potential Therapeutic Targets for Pulmonary Arterial Hypertension
    Li, Aoqi
    He, Jin
    Zhang, Zhe
    Jiang, Sibo
    Gao, Yun
    Pan, Yuchun
    Wang, Huanan
    Zhuang, Lenan
    GENES, 2021, 12 (09)
  • [42] Identification of potential biomarkers and therapeutic targets for human IgA nephropathy and hypertensive nephropathy by bioinformatics analysis
    Cui, Yingchun
    Liu, Shengmao
    Cui, Wenpeng
    Gao, Dan
    Zhou, Wenhua
    Luo, Ping
    MOLECULAR MEDICINE REPORTS, 2017, 16 (03) : 3087 - 3094
  • [43] Potential mechanisms and therapeutic targets of mesenchymal stem cell transplantation for ischemic stroke
    Li Zhou
    Huimin Zhu
    Xue Bai
    Jiagui Huang
    Yue Chen
    Jun Wen
    Xuemei Li
    Bowen Wu
    Yongjun Tan
    Mingfen Tian
    Jiangxia Ren
    Mengxia Li
    Qin Yang
    Stem Cell Research & Therapy, 13
  • [44] Potential diagnostic markers and therapeutic targets for periodontitis and Alzheimer's disease based on bioinformatics analysis
    Yang, Kai
    Zhang, Zhaoqi
    Zhang, Qingyuan
    Zhang, Hongyu
    Liu, Xiaoju
    Jia, Zhicheng
    Ying, Zhenhao
    Liu, Wei
    JOURNAL OF PERIODONTAL RESEARCH, 2024, 59 (02) : 366 - 380
  • [45] Imagiomics of HCC combined with bioinformatics to analyze potential therapeutic targets for HCC
    Chen, Hongyu
    Yan, Lijun
    JOURNAL OF RADIATION RESEARCH AND APPLIED SCIENCES, 2025, 18 (01)
  • [46] Renal Cell Carcinoma Cancer Stem Cells as Therapeutic Targets
    Czarnecka, Anna M.
    Szczylik, Cezary
    CURRENT SIGNAL TRANSDUCTION THERAPY, 2013, 8 (03) : 203 - 209
  • [47] Novel therapeutic targets to improve IVF outcomes in endometriosis patients: a review and future prospects
    Corachan, Ana
    Pellicer, Nuria
    Pellicer, Antonio
    Ferrero, Hortensia
    HUMAN REPRODUCTION UPDATE, 2021, 27 (05) : 923 - 943
  • [48] Identification of MCM family as potential therapeutic and prognostic targets for hepatocellular carcinoma based on bioinformatics and experiments
    Lei, Yu
    Wang, Shuhui
    Liu, Jingmei
    Yan, Wei
    Han, Ping
    Tian, Dean
    LIFE SCIENCES, 2021, 272
  • [49] Identification of potential therapeutic target genes and mechanisms in head and neck squamous cell carcinoma by bioinformatics analysis
    Kuang, Jing
    Zhao, Mei
    Li, Huilian
    Dang, Wei
    Li, Wei
    ONCOLOGY LETTERS, 2016, 11 (05) : 3009 - 3014
  • [50] Analysis of the key prognostic genes and potential traditional Chinese medicine therapeutic targets in glioblastoma based on bioinformatics and network pharmacology methods
    Xia, Zhiyu
    Gao, Peng
    Chen, Yu
    Shu, Lei
    Ye, Lei
    Cheng, Hongwei
    Dai, Xingliang
    Hu, Yangchun
    Wang, Zhongyong
    TRANSLATIONAL CANCER RESEARCH, 2022, : 1386 - 1405
12345