Endometriosis stem cell sources and potential therapeutic targets: literature review and bioinformatics analysis

被引：3
|
作者：
Jin, Zhe [1 ,2 ]
Zhang, Yize [1 ,2 ]
Li, Jingyi [3 ]
Lv, Sidi [1 ,2 ]
Zhang, Lixia [4 ]
Feng, Ying [1 ]
机构：
[1] Nanchang Univ, Affiliated Hosp 2, Nanchang 330006, Jiangxi, Peoples R China
[2] Nanchang Univ, Clin Med Sch 2, Nanchang 330031, Jiangxi, Peoples R China
[3] Nanchang Univ, Sch Publ Hlth, Nanchang 330031, Jiangxi, Peoples R China
[4] First Hosp Handan City, Handan 056004, Hebei, Peoples R China
来源：
REGENERATIVE MEDICINE | 2021年 / 16卷 / 10期
关键词：
CXCL12/CXCR4; endometriosis; MMPs/TIMPs; stem cells; survivin (BIRC5); therapeutic targets; VEGF/HIF-1; alpha; ENDOTHELIAL GROWTH-FACTOR; PROGENITOR CELLS; STROMAL CELLS; EXPRESSION; MIGRATION; APOPTOSIS; SURVIVIN; WOMEN; PROLIFERATION; ANGIOGENESIS;
D O I：
10.2217/rme-2021-0039
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
The stem cell origin theory of endometriosis (EMS) is a significant area of new research but the sources of this have yet to be adequately summarized. Existing treatments for EMS are commonly associated with a high recurrence rate; consequently, there is an urgent need to develop new therapeutic measures for the future treatment of this disease from the view of stem cells and gene therapy. Recently, we describe the evidence for the potential sources of EMS stem cells and other key molecules participating in the establishment of lesions, and predict the miRNAs that target these key genes via bioinformatics analysis for further research. The review highlights the origin of EMS stem cells and potential therapy targets.
引用
收藏
页码：949 / 962
页数：14
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