Expeditious Synthesis of Phenanthridines from Benzylamines via Dual Palladium Catalysis

被引：99
|
作者：
Maestri, Giovanni [1 ]
Larraufie, Marie-Helene [1 ]
Derat, Etienne [1 ]
Ollivier, Cyril [1 ]
Fensterbank, Louis [1 ]
Lacote, Emmanuel [1 ]
Malacria, Max [1 ]
机构：
[1] Univ Paris 06, UPMC, Inst Parisien Chim Mol, UMR CNRS 7201, F-75005 Paris, France
来源：
ORGANIC LETTERS | 2010年 / 12卷 / 24期
关键词：
C-H ACTIVATION; REDUCTIVE ELIMINATION; ARYL HALIDES; COUPLING REACTIONS; BOND FORMATION; OLEFINS; METALATION; COMPLEXES; ARYLATION; ANTITUMOR;
D O I：
10.1021/ol102509n
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A method for the synthesis of phenanthridines from benzylamines and aryl iodides which uses a dual palladium-catalyzed process is developed. The domino sequence ends via an intramolecular amination and an oxidative dehydrogenation. No protecting group or prefunctionalization of the amine is required, and the process uses dioxygen as the terminal oxidant.
引用
收藏
页码：5692 / 5695
页数：4
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