Report of the ECCO workshop on anti-TNF therapy failures in inflammatory bowel diseases: Biological roles and effects of TNF and TNF antagonists

被引：42

作者：

Chowers, Yehuda ^{[2
]}

Sturm, Andreas ^{[3
]}

Sans, Miquel ^{[4
]}

Papadakis, Konstantinos ^{[5
]}

Gazouli, Maria ^{[6
]}

Harbord, Marcus ^{[7
]}

Jahnel, Joerg ^{[8
]}

Mantzaris, Gerassimos J. ^{[9
]}

Meier, Johannes ^{[3
]}

Mottet, Christian ^{[10
]}

Peyrin-Biroulet, Laurent ^{[11
,12
]}

Allez, Matthieu ^{[1
,13
]}

机构：

[1] Univ Paris 07, Hop St Louis, APHP, Dept Gastroenterol, F-75010 Paris, France

[2] Technion Israel Inst Technol, Haifa & Rappoport Sch Med, Dept Gastroenterol, IL-32000 Haifa, Israel

[3] Charite, Campus Virchow Clin, Dep Gastroenterol & Hepatol, D-13353 Berlin, Germany

[4] CIBER EHD, Hosp Clin IDIBAPS, Dept Gastroenterol, Barcelona, Spain

[5] Univ Crete, Fac Med, Univ Hosp Heraklion, Dept Gastroenterol, Iraklion, Crete, Greece

[6] Univ Athens, Sch Med, Dept Biol, GR-10679 Athens, Greece

[7] Chelsea & Westminster Hosp Fdn Trust, Dept Gastroenterol, London, England

[8] Med Univ Graz, Graz, Austria

[9] Evangelismos Med Ctr, Dept Gastroenterol A, Athens, Greece

[10] Hop Neuchatelois, Gastroenterol Unit, Neuchatel, Switzerland

[11] Nancy Univ Hosp, Dept Gastroenterol, Vandoeuvre Les Nancy, France

[12] Nancy Univ Hosp, INSERM, U954, Vandoeuvre Les Nancy, France

[13] Univ Paris 07, Hop St Louis, APHP, Equipe Avenir,INSERM,U940, F-75010 Paris, France

来源：

JOURNAL OF CROHNS & COLITIS | 2010年 / 4卷 / 04期

关键词：

Inflammatory bowel diseases; Crohn's disease; Ulcerative colitis; TNF alpha; Anti-TNF therapy; Paradoxical inflammation; TUMOR-NECROSIS-FACTOR; ACTIVE CROHNS-DISEASE; REGULATORY T-CELLS; FACTOR-ALPHA; FACTOR RECEPTORS; IN-VITRO; INDUCIBLE COSTIMULATOR; MONOCLONAL-ANTIBODY; INTESTINAL INFLAMMATION; TRANSMEMBRANE FORM;

D O I：

10.1016/j.crohns.2010.05.011

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

This second section of the first ECCO pathogenesis workshop on anti-TNF therapy failures in inflammatory bowel diseases addresses the biological roles of TNF alpha and the effects and mechanisms of action of TNF alpha antagonists. Mechanisms underlying their failure, including induction of TNF-independent inflammatory pathways and phenomena of paradoxical inflammation are discussed. (C) 2010 European Crohn's and Colitis Organisation. Published by Elsevier B.V. All rights reserved.

引用

页码：367 / 376

页数：10

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