Tel2: a common partner of PIK-related kinases and a link between DNA checkpoint and nutritional response?

被引：17
作者：
Kanoh, Junko
Yanagida, Mitsuhiro
机构：
[1] Kyoto Univ, Grad Sch Biostudies, Sakyo Ku, Kyoto 6068501, Japan
[2] Okinawa Inst Sci & Technol Promot Corp, G0 Cell Unit, Okinawa 9042234, Japan
来源：
GENES TO CELLS | 2007年 / 12卷 / 12期
关键词：
D O I：
10.1111/j.1365-2443.2007.01142.x
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
A recent paper (Hayashi et al. 2007) in this issue of Genes to Cells shows that the fission yeast Schizosaccharomyces pombe Tel2, a homologue of mammalian/worm CLK2/Clk-2/Rad-5, physically interacts with all the phosphoinositide 3-kinase-related kinases (PIKKs) that include Rad3/Tel1 (ATR/ATM homologues), Tor1/Tor2 (TOR kinases) and Tra1/Tra2 (TRRAP homologues), raising the possibility that Tel2 family proteins link various PIKK-related cellular processes by interacting with PIKK family proteins. In this minireview, implications and impact of the findings, and a possibility that PIKKs are functionally related through Tel2, are discussed.
引用
收藏
页码：1301 / 1304
页数：4
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