Host-bacterial mutualism in the human intestine

被引：3840

作者：

Bäckhed, F ^{[1
]}

Ley, RE ^{[1
]}

Sonnenburg, JL ^{[1
]}

Peterson, DA ^{[1
]}

Gordon, JI ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Ctr Genome Sci, St Louis, MO 63108 USA

来源：

SCIENCE | 2005年 / 307卷 / 5717期

关键词：

D O I：

10.1126/science.1104816

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The distal human intestine represents an anaerobic bioreactor programmed with an enormous population of bacteria, dominated by relatively few divisions that are highly diverse at the strain/subspecies level. This microbiota and its collective genomes (microbiome) provide us with genetic and metabolic attributes we have not been required to evolve on our own, including the ability to harvest otherwise inaccessible nutrients. New studies are revealing how the gut microbiota has co-evolved with us and how it manipulates and complements our biology in ways that are mutually beneficial. We are also starting to understand how certain keystone members of the microbiota operate to maintain the stability and functional adaptability of this microbial organ.

引用

页码：1915 / 1920

页数：6

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