Synthesis and bioactivities of 6,7,8-trimethoxy-N-aryl-4-aminoquinazoline derivatives

被引：21

作者：

Liu, Gang ^{[1
]}

Hu, De-Yu ^{[1
]}

Jin, Lin-Hong ^{[1
]}

Song, Bao-An ^{[1
]}

Yang, Song ^{[1
]}

Liu, Ping-Shen ^{[1
]}

Bhadury, Pinaki S. ^{[1
]}

Ma, Yao ^{[1
]}

Luo, Hui ^{[1
]}

Zhou, Man ^{[1
]}

机构：

[1] Guizhou Univ, Key Lab Fine Chem Guizhou Prov, Minist Educ,Key Lab Green Pesticide & Bioengn, Ctr Res & Dev Fine Chem, Guiyang 550025, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2007年 / 15卷 / 20期

基金：

中国国家自然科学基金;

关键词：

quinazoline; amino moiety; gallic acid; synthesis; anticancer activities;

D O I：

10.1016/j.bmc.2007.07.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of 4-aminoquinazoline derivatives is prepared by the nucleophilic substitution reaction of 6,7,8-trimethoxy-4-chloroquinazoline and aryl amine. The structures of the compounds are confirmed by elemental analysis, IR, and H-1 NMR spectral data. The compounds are also evaluated for their ability to inhibit tumor cells PC3, A431, Beap-37, and BGC823 by MTT assays. Among them, 6b and 6e are found as potent inhibitors, with IC50 values ranging from 5.8 to 9.8 mu M, in vitro assay. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：6608 / 6617

页数：10

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