Insights into host responses against pathogens from transcriptional profiling

被引：437
作者：
Jenner, RG
Young, RA
机构：
[1] Whitehead Inst Biomed Res, Cambridge, MA 02142 USA
[2] MIT, Dept Biol, Cambridge, MA 02139 USA
[3] MIT, Broad Inst, Cambridge, MA 02139 USA
[4] Harvard Univ, Cambridge, MA 02139 USA
来源：
NATURE REVIEWS MICROBIOLOGY | 2005年 / 3卷 / 04期
关键词：
D O I：
10.1038/nrmicro1126
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
DNA microarrays have allowed us to monitor the effects of pathogens on host-cell gene expression programmes in great depth and on a broad scale. The comparison of results that have been generated by these studies is complex, and such a comparison has not previously been attempted in a systematic manner. In this review, we have collated and compared published transcriptional-profiling data from 32 studies that involved 77 different host-pathogen interactions, and have defined a common host-transcriptional-response. We outline gene expression patterns in the context of Toll-like receptor and pathogen-mediated signalling pathways, and summarize the contributions that transcriptional-profiling studies have made to our understanding of the infectious disease process.
引用
收藏
页码：281 / 294
页数：14
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