Insights into host responses against pathogens from transcriptional profiling

被引：437

作者：

Jenner, RG

Young, RA

机构：

[1] Whitehead Inst Biomed Res, Cambridge, MA 02142 USA

[2] MIT, Dept Biol, Cambridge, MA 02139 USA

[3] MIT, Broad Inst, Cambridge, MA 02139 USA

[4] Harvard Univ, Cambridge, MA 02139 USA

来源：

NATURE REVIEWS MICROBIOLOGY | 2005年 / 3卷 / 04期

关键词：

D O I：

10.1038/nrmicro1126

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

DNA microarrays have allowed us to monitor the effects of pathogens on host-cell gene expression programmes in great depth and on a broad scale. The comparison of results that have been generated by these studies is complex, and such a comparison has not previously been attempted in a systematic manner. In this review, we have collated and compared published transcriptional-profiling data from 32 studies that involved 77 different host-pathogen interactions, and have defined a common host-transcriptional-response. We outline gene expression patterns in the context of Toll-like receptor and pathogen-mediated signalling pathways, and summarize the contributions that transcriptional-profiling studies have made to our understanding of the infectious disease process.

引用

收藏

页码：281 / 294

页数：14

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