Serial bipolar androgen therapy (sBAT) using cyclic supraphysiologic testosterone (STP) to treat metastatic castration-resistant prostate cancer (mCRPC)

被引:10
作者
Isaacs, John T. [1 ,2 ,3 ]
Brennen, W. Nathaniel [1 ,2 ,3 ]
Denmeade, Samuel R. [1 ,2 ,3 ]
机构
[1] Johns Hopkins, Dept Oncol, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21231 USA
[2] Brady Urol Inst, Baltimore, MD 21287 USA
[3] Johns Hopkins Univ, Sch Med, Dept Urol, Baltimore, MD 21205 USA
关键词
CELL-PROLIFERATION; RECEPTOR; GROWTH; RECRUITMENT; INHIBITION; CONVERSION; SUPPRESSOR; EXPRESSION; RATIONALE; GAIN;
D O I
10.21037/atm.2019.10.32
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
引用
收藏
页数:4
相关论文
共 22 条
[1]   Androgen receptor (AR) suppresses normal human prostate epithelial cell proliferation via AR/-catenin/TCF-4 complex inhibition of c-MYC transcription [J].
Antony, Lizamma ;
van der Schoor, Freek ;
Dalrymple, Susan L. ;
Isaacs, John T. .
PROSTATE, 2014, 74 (11) :1118-1131
[2]   Androgen Receptor Gene Expression in Prostate Cancer Is Directly Suppressed by the Androgen Receptor Through Recruitment of Lysine-Specific Demethylase 1 [J].
Cai, Changmeng ;
He, Housheng Hansen ;
Chen, Sen ;
Coleman, Ilsa ;
Wang, Hongyun ;
Fang, Zi ;
Chen, Shaoyong ;
Nelson, Peter S. ;
Liu, X. Shirley ;
Brown, Myles ;
Balk, Steven P. .
CANCER CELL, 2011, 20 (04) :457-471
[3]   Supraphysiological androgens suppress prostate cancer growth through androgen receptor-mediated DNA damage [J].
Chatterjee, Payel ;
Schweizer, Michael T. ;
Lucas, Jared M. ;
Coleman, Ilsa ;
Nyquist, Michael D. ;
Frank, Sander B. ;
Tharakan, Robin ;
Mostaghel, Elahe ;
Luo, Jun ;
Pritchard, Colin C. ;
Lam, Hung-Ming ;
Corey, Eva ;
Antonarakis, Emmanuel S. ;
Denmeade, Samuel R. ;
Nelson, Peter S. .
JOURNAL OF CLINICAL INVESTIGATION, 2019, 129 (10) :4245-4260
[4]   DNA licensing as a novel androgen receptor mediated therapeutic target for prostate cancer [J].
D'Antonio, Jason M. ;
Griend, Donald J. Vander ;
Isaacs, John T. .
ENDOCRINE-RELATED CANCER, 2009, 16 (02) :325-332
[5]   Bipolar Androgen Therapy: The Rationale for Rapid Cycling of Supraphysiologic Androgen/Ablation in Men With Castration Resistant Prostate Cancer [J].
Denmeade, Samuel R. ;
Isaacs, John T. .
PROSTATE, 2010, 70 (14) :1600-1607
[6]  
Gao J, 2001, CANCER RES, V61, P5038
[7]   Androgen Receptor Tumor Suppressor Function Is Mediated by Recruitment of Retinoblastoma Protein [J].
Gao, Shuai ;
Gao, Yanfei ;
He, Housheng Hansen ;
Han, Dong ;
Han, Wanting ;
Avery, Amy ;
Macoska, Jill A. ;
Liu, Xiaming ;
Chen, Sen ;
Ma, Fen ;
Chen, Shaoyong ;
Balk, Steven P. ;
Cai, Changmeng .
CELL REPORTS, 2016, 17 (04) :966-976
[8]   Transcription-Induced DNA Double Strand Breaks: Both Oncogenic Force and Potential Therapeutic Target? [J].
Haffner, Michael C. ;
De Marzo, Angelo M. ;
Meeker, Alan K. ;
Nelson, William G. ;
Yegnasubramanian, Srinivasan .
CLINICAL CANCER RESEARCH, 2011, 17 (12) :3858-3864
[9]   Androgen-induced TOP2B-mediated double-strand breaks and prostate cancer gene rearrangements [J].
Haffner, Michael C. ;
Aryee, Martin J. ;
Toubaji, Antoun ;
Esopi, David M. ;
Albadine, Roula ;
Gurel, Bora ;
Isaacs, William B. ;
Bova, G. Steven ;
Liu, Wennuan ;
Xu, Jianfeng ;
Meeker, Alan K. ;
Netto, George ;
De Marzo, Angelo M. ;
Nelson, William G. ;
Yegnasubramanian, Srinivasan .
NATURE GENETICS, 2010, 42 (08) :668-U45
[10]   Adaptive auto-regulation of androgen receptor provides a paradigm shifting rationale for bipolar androgen therapy (BAT) for castrate resistant human prostate cancer [J].
Isaacs, John T. ;
D'Antonio, Jason M. ;
Chen, Shuangling ;
Antony, Lizamma ;
Dalrymple, Susan P. ;
Ndikuyeze, Georges H. ;
Luo, Jun ;
Denmeade, Samuel R. .
PROSTATE, 2012, 72 (14) :1491-1505