Investigation of transcription factor AP-2beta genotype in women with premenstrual dysphoric disorder

被引:11
作者
Damberg, M [1 ]
Westberg, L
Berggård, C
Landen, M
Sundblad, C
Eriksson, O
Naessén, T
Ekman, A
Eriksson, E
机构
[1] Uppsala Univ, Dept Neurosci, Pharmacol Unit, Uppsala, Sweden
[2] Univ Gothenburg, Dept Pharmacol, Gothenburg, Sweden
[3] Univ Gothenburg, Inst Clin Neurosci, Sect Psychiat, Gothenburg, Sweden
[4] Uppsala Univ, Dept Womens & Childrens Hlth Obstet & Gynecol, Uppsala, Sweden
关键词
5-HT; premenstrual dysphoria; monoamines; transcription factor; AP-2; gene expression;
D O I
10.1016/j.neulet.2004.11.068
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
It has repeatedly been shown that the serotonergic system is involved in the symptomatology of premenstrual dysphoric disorder (PMDD). Women with PMDD are reported to differ from symptom-free controls with regard to serotonin-related biological markers. Evidence from family and twin studies suggests a genetic contribution to the aetiology of PMDD. The expression of human transcription factor AP-2beta in neural crest cell lineages and neuroectodermal cells suggests that this protein may be of importance for functional characteristics of neurons by regulating the expression of target genes. Within the monoaminergic systems, several genes have binding sites for AP-2beta in regulatory regions, suggesting an involvement of AP-2beta in these systems. The gene encoding AP-2beta is located on chromosome 6pl2-p2l.1 and includes a polymorphic region consisting of a variable number of [CAAA] repeats located in the second intron. We have earlier shown that AP-2beta genotype is associated with serotonergic phenotypes and that brainstem levels of AP-2beta correlate positively to serotonin metabolism in rat frontal cortex. The aim of this study was to investigate the relationship between PMDD and transcription factor AP-2beta genotype. The participants included 176 women with PMDD and 91 healthy controls. Genotyping was performed by polymerase chain reactions. We did not observe any differences in AP-2beta genotype frequencies between PMDD subjects and controls. Our results suggest that AP-2beta genotype is not a risk factor for PMDD. To our knowledge, this is the first study investigating transcription factor AP-2beta genotype in women with PMDD. Hence, these results should be considered preliminary until replicated. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:49 / 52
页数:4
相关论文
共 26 条
  • [1] The epidemiology of perimenstrual psychological symptoms
    Angst, J
    Sellaro, R
    Stolar, M
    Merikangas, KR
    Endicott, J
    [J]. ACTA PSYCHIATRICA SCANDINAVICA, 2001, 104 (02) : 110 - 116
  • [2] FAST AND SENSITIVE SILVER STAINING OF DNA IN POLYACRYLAMIDE GELS
    BASSAM, BJ
    CAETANOANOLLES, G
    GRESSHOFF, PM
    [J]. ANALYTICAL BIOCHEMISTRY, 1991, 196 (01) : 80 - 83
  • [3] Tryptophan depletion increases aggression in women during the premenstrual phase
    Bond, AJ
    Wingrove, J
    Critchlow, DG
    [J]. PSYCHOPHARMACOLOGY, 2001, 156 (04) : 477 - 480
  • [4] Polymorphisms of the human IFNG gene noncoding regions
    Bream, JH
    Carrington, M
    O'Toole, S
    Dean, M
    Gerrard, B
    Shin, HD
    Kosack, D
    Modi, W
    Young, HA
    Smith, MW
    [J]. IMMUNOGENETICS, 2000, 51 (01) : 50 - 58
  • [5] BRZEZINSKI AA, 1990, OBSTET GYNECOL, V76, P296
  • [6] AP-2.2, a novel gene related to AP-2, is expressed in the forebrain, limbs and face during mouse embryogenesis
    Chazaud, C
    OuladAbdelghani, M
    Bouillet, P
    Decimo, D
    Chambon, P
    Dolle, P
    [J]. MECHANISMS OF DEVELOPMENT, 1996, 54 (01) : 83 - 94
  • [7] THE PREMENSTRUAL-SYNDROME - A TWIN STUDY
    CONDON, JT
    [J]. BRITISH JOURNAL OF PSYCHIATRY, 1993, 162 : 481 - 486
  • [8] A polymorphic region in the human transcription factor AP-2β gene is associated with specific personality traits
    Damberg, M
    Garpenstrand, H
    Alfredsson, J
    Ekblom, J
    Forslund, K
    Rylander, G
    Oreland, L
    [J]. MOLECULAR PSYCHIATRY, 2000, 5 (02) : 220 - 224
  • [9] The genotype of human transcription factor AP-2β is associated with platelet monoamine oxidase B activity
    Damberg, M
    Garpenstrand, H
    Berggård, C
    Åsberg, M
    Hallman, J
    Oreland, L
    [J]. NEUROSCIENCE LETTERS, 2000, 291 (03) : 204 - 206
  • [10] Transcription factor AP-2β genotype, striatal dopamine D2 receptor density and cerebrospinal fluid monoamine metabolite concentrations in humans
    Damberg, M
    Berggård, C
    Farde, L
    Sedvall, GC
    Jönsson, EG
    [J]. JOURNAL OF NEURAL TRANSMISSION, 2004, 111 (04) : 537 - 545