A new biodegradable nano cellulose-based drug delivery system for pH-controlled delivery of curcumin

被引：53

作者：

Anirudhan, T. S. ^{[1
]}

Manjusha, V. ^{[1
]}

Sekhar, V. Chithra ^{[1
]}

机构：

[1] Univ Kerala, Sch Phys & Math Sci, Dept Chem, Res Ctr, Trivandrum 695581, Kerala, India

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2021年 / 183卷

关键词：

Nano cellulose; Targeted drug delivery; pH-responsive delivery; CARRIER; NANOCELLULOSE; NANOPARTICLES; ADSORPTION; HYDROGELS;

D O I：

10.1016/j.ijbiomac.2021.06.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Targeted delivery and controlled release of drugs are attractive methods for avoiding the drug's leakage during blood circulation and burst release of the drug. We prepared a nano cellulose-based drug delivery system (DDS) for the effective delivery of curcumin (CUR). In the present scenario, the role of nanoparticles in fabricating the DDS is an important one and was characterized using various techniques. The drug loading capacity was high as 89.2% at pH = 8.0, and also the maximum drug release takes place at pH = 5.5. In vitro cell viability studies of DDS on MDA MB-231; breast cancer cells demonstrated its cytotoxicity towards cancer cells. The prepared DDS was also examined for apoptosis, hemocompatibility, and Chorioallantoic membrane (CAM) studies to assess its pharmaceutical field application and the investigation results recommended that it may serve as a potential device for targeted delivery and controlled release of CUR for cancer treatment.

引用

页码：2044 / 2054

页数：11

共 33 条

[1] Graphene oxide based functionalized chitosan polyelectrolyte nanocomposite for targeted and pH responsive drug delivery [J].

Anirudhan, T. S. ;

Sekhar, V. Chithra ;

Athira, V. S. .

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2020, 150 :468-479

[2] Nanoparticle assisted solvent selective transdermal combination therapy of curcumin and 5-flurouracil for efficient cancer treatment [J].

Anirudhan, T. S. ;

Nair, Anoop S. ;

Bino, Sabari J. .

CARBOHYDRATE POLYMERS, 2017, 173 :131-142

[3] Synthesis and characterisation of chitosan crosslinked-β-cyclodextrin grafted silylated magnetic nanoparticles for controlled release of Indomethacin [J].

Anirudhan, T. S. ;

Dilu, D. ;

Sandeep, S. .

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS, 2013, 343 :149-156

[4] Poly(acrylic acid)-modified poly(glycidylmethacrylate)-grafted nanocellulose as matrices for the adsorption of lysozyme from aqueous solutions [J].

Anirudhan, T. S. ;

Rejeena, S. R. .

CHEMICAL ENGINEERING JOURNAL, 2012, 187 :150-159

[5] Synthesis, characterization and in vitro cytotoxicity analysis of a novel cellulose based drug carrier for the controlled delivery of 5-fluorouracil, an anticancer drug [J].

Anirudhan, Thayyath S. ;

Nima, Jayachandran ;

Divya, Peethambaran L. .

APPLIED SURFACE SCIENCE, 2015, 355 :64-73

[6] Synthesis and characterization of silane coated magnetic nanoparticles/glycidylmethacrylate-grafted-maleated cyclodextrin composite hydrogel as a drug carrier for the controlled delivery of 5-fluorouracil [J].

Anirudhan, Thayyath S. ;

Divya, Peethambaran L. ;

Nima, Jayachandran .

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2015, 55 :471-481

[7] Selective adsorption of hemoglobin using polymer-grafted-magnetite nanocellulose composite [J].

Anirudhan, Thayyath Sreenivasan ;

Rejeena, Sylaja Raveendran .

CARBOHYDRATE POLYMERS, 2013, 93 (02) :518-527

[8]

Bisht S., 2007, J NANOBIOTECHNOL, V18, P1

[9] Synthesis and hydration properties of pH-sensitive p(HEMA)-based hydrogels containing 3-(trimethoxysilyl)propyl methacrylate [J].

Brahim, S ;

Narinesingh, D ;

Guiseppi-Elie, A .

BIOMACROMOLECULES, 2003, 4 (03) :497-503

[10] Cellulose nanocrystals and cellulose nanofibrils based hydrogels for biomedical applications [J].

Du, Haishun ;

Liu, Wei ;

Zhang, Miaomiao ;

Si, Chuanling ;

Zhang, Xinyu ;

Li, Bin .

CARBOHYDRATE POLYMERS, 2019, 209 :130-144

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