Asymmetric synthesis of (+)-chloriolide

被引：12

作者：

Das, Tapas ^{[1
]}

Jana, Nandan ^{[1
]}

Nanda, Samik ^{[1
]}

机构：

[1] Indian Inst Technol, Dept Chem, Kharagpur 721302, W Bengal, India

来源：

TETRAHEDRON LETTERS | 2010年 / 51卷 / 19期

关键词：

Medium ring macrolides; Enzymatic kinetic resolution (EKR); Asymmetric alkynylation; Macrolactonization; Asymmetric total synthesis; ENANTIOSELECTIVE TOTAL-SYNTHESIS; PATULOLIDE-C; MACROLIDES; CONVERSION; ROUTE; METABOLITES; ALDEHYDES; ALCOHOLS; BENZYL;

D O I：

10.1016/j.tetlet.2010.03.028

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An asymmetric synthesis of 12-membered ring macrolide, chloriolide has been accomplished by adopting a linear strategy. Lipase-catalyzed enzymatic kinetic resolution (EKR), asymmetric alkynylation using Trost pro-phenol catalyst followed by Yamaguchi macrolactonization has been successfully employed to achieve the target molecule. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：2644 / 2647

页数：4

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