Two new lactones and one new aryl-8-oxa-bicyclo[3,2,1]oct-3-en-2-one from Descurainia sophia

被引：42

作者：

Sun, K

Li, X ^{[1
]}

Li, W

Wang, JH

Liu, JM

Sha, Y

机构：

[1] Shenyang Pharmaceut Univ, Res Dept Nucl Med, Shenyang 110016, Peoples R China

[2] Shenyang Pharmaceut Univ, Ctr Instrumental Anal, Shenyang 110016, Peoples R China

[3] Yisheng Pharmaceut Co Ltd, Res Dept, Jian 134200, Peoples R China

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2004年 / 52卷 / 12期

关键词：

Descurainia sophia; lactone; aryl-8-oxa-bicyclo[3,2,1]-oct-3-cn-2-one; nor-lignan; cytotoxicity;

D O I：

10.1248/cpb.52.1483

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two new lactones (1, 2), descurainolide A and B, and one new aryl-8-oxa-bicyclo[3,2,1]-oct-3-en-2-one (3), descurainin, together with five known compounds (4-8), were isolated from the seeds of Descurainia sophia (L.) Webb ex Prantl. The structures of the new compounds were elucidated by extensive studies of their 1D, 2D NMR and HR-MS. Compounds 4 and 5 showed cytotoxicity.

引用

页码：1483 / 1486

页数：4

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