Synthesis of Novel α-Trifluorothioanisole Derivatives Containing Phenylpyridine Moieties with Herbicidal Activity

被引：1

作者：

Cai, Zengfei ^{[1
]}

Zhang, Wenliang ^{[1
]}

Yan, Zhongjie ^{[2
]}

Du, Xiaohua ^{[1
]}

机构：

[1] Zhejiang Univ Technol, Catalyt Hydrogenat Res Ctr, Zhejiang Green Pesticide Collaborat Innovat Ctr, Zhejiang Key Lab Green Pesticides & Cleaner Prod, Hangzhou 310014, Peoples R China

[2] Agrowin Ningbo Biosci Co Ltd, Ningbo 315100, Peoples R China

来源：

MOLECULES | 2022年 / 27卷 / 18期

关键词：

synthesis; alpha-trifluorothioanisole derivatives; phenylpyridine; herbicidal activity; SULFONE DERIVATIVES; DISCOVERY; TRIFLUOROMETHYLTHIOLATION; 1,3,4-OXADIAZOLE; DESIGN;

D O I：

10.3390/molecules27185879

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

To discover novel herbicidal compounds with favorable activity, a range of phenylpyridinemoiety-containing alpha-trifluorothioanisole derivatives were designed, synthesized, and identified via NMR and HRMS. Preliminary screening of greenhouse-based herbicidal activity revealed that compound 5a exhibited >85% inhibitory activity against broadleaf weeds Amaranthus retroflexus, Abutilon theophrasti, and Eclipta prostrate at 37.5 g a.i./hm(2), which was slightly superior to that of fomesafen. The current study suggests that compound 5a could be further optimized as an herbicide candidate to control various broadleaf weeds.

引用

页数：9

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