Non-invasive optical mapping of the piglet brain in real time

被引：38
作者：
Fantini, S
Franceschini, MA
Gratton, E
Hueber, D
Rosenfeld, W
Maulik, D
Stubblefield, PG
Stankovic, MR
机构：
[1] Univ Illinois, Dept Phys, Fluorescence Dynam Lab, Urbana, IL 61801 USA
[2] ISS Inc, Champaign, IL 61821 USA
[3] SUNY Stony Brook, Winthrop Univ Hosp, Sch Med, Dept Obstet Gynecol, Mineola, NY 11501 USA
[4] SUNY Stony Brook, Winthrop Univ Hosp, Sch Med, Dept Pediat, Mineola, NY 11501 USA
[5] Boston Univ, Sch Med, Dept Obstet & Gynecol, Boston, MA 02118 USA
来源：
OPTICS EXPRESS | 1999年 / 4卷 / 08期
关键词：
D O I：
10.1364/OE.4.000308
中图分类号：
O43 [光学];
学科分类号：
070207 ; 0803 ;
摘要：
We have performed non-invasive, real-time optical mapping of the piglet brain during a subcortical injection of autologous blood. The time resolution of the optical maps is 192 ms, thus allowing us to generate a real-time video of the growing subcortical hematoma. The increased absorption at the site of blood injection is accompanied by a decreased absorption at the contralateral brain side. This contralateral decrease in the optical absorption and the corresponding time traces of the cerebral hemoglobin parameters are consistent with a reduced cerebral blood flow caused by the increased intracranial pressure. (C) 1999 Optical Society of America.
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收藏
页码：308 / 314
页数：7
相关论文
共 18 条
[1]   A novel method for fast imaging of brain function, non-invasively, with light [J].
Chance, B ;
Anday, E ;
Nioka, S ;
Zhou, S ;
Hong, L ;
Worden, K ;
Li, C ;
Murray, T ;
Ovetsky, Y ;
Pidikiti, D ;
Thomas, R .
OPTICS EXPRESS, 1998, 2 (10) :411-423
[2]  
Chance B, 1999, P SPIE, V3597
[3]   Regional imager for low-resolution functional imaging of the brain with diffusing near-infrared light [J].
Danen, RM ;
Wang, Y ;
Li, XD ;
Thayer, WS ;
Yodh, AG .
PHOTOCHEMISTRY AND PHOTOBIOLOGY, 1998, 67 (01) :33-40
[4]   ESTIMATION OF OPTICAL PATHLENGTH THROUGH TISSUE FROM DIRECT TIME OF FLIGHT MEASUREMENT [J].
DELPY, DT ;
COPE, M ;
VANDERZEE, P ;
ARRIDGE, S ;
WRAY, S ;
WYATT, J .
PHYSICS IN MEDICINE AND BIOLOGY, 1988, 33 (12) :1433-1442
[5]   SEMI-INFINITE-GEOMETRY BOUNDARY-PROBLEM FOR LIGHT MIGRATION IN HIGHLY SCATTERING MEDIA - A FREQUENCY-DOMAIN STUDY IN THE DIFFUSION-APPROXIMATION [J].
FANTINI, S ;
FRANCESCHINI, MA ;
GRATTON, E .
JOURNAL OF THE OPTICAL SOCIETY OF AMERICA B-OPTICAL PHYSICS, 1994, 11 (10) :2128-2138
[6]  
FANTINI S, UNPUB PHYS MED BIOL
[7]  
Franceschini M A, 1997, J Biomed Opt, V2, P147, DOI 10.1117/12.262145
[8]   Influence of a superficial layer in the quantitative spectroscopic study of strongly scattering media [J].
Franceschini, MA ;
Fantini, S ;
Paunescu, LA ;
Maier, JS ;
Gratton, E .
APPLIED OPTICS, 1998, 37 (31) :7447-7458
[9]   TRANSILLUMINATION IMAGING PERFORMANCE - SPATIAL-RESOLUTION SIMULATION STUDIES [J].
HEBDEN, JC ;
KRUGER, RA .
MEDICAL PHYSICS, 1990, 17 (01) :41-47
[10]   Stationary headband for clinical time-of-flight optical imaging at the bedside [J].
Hintz, SR ;
Benaron, DA ;
van Houten, JP ;
Duckworth, JL ;
Liu, FWH ;
Spilman, SD ;
Stevenson, DK ;
Cheong, WF .
PHOTOCHEMISTRY AND PHOTOBIOLOGY, 1998, 68 (03) :361-369
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