Aldol reactions on solid phase. Sc(OTf)(3)-catalyzed aldol reactions of polymer-supported silyl enol ethers with aldehydes providing convenient methods for the preparation of 1,3-diol,beta-hydroxy carboxylic acid, and beta-hydroxy aldehyde libraries

被引：48

作者：

Kobayashi, S

Hachiya, I

Yasuda, M

机构：

[1] Department of Applied Chemistry, Faculty of Science, Science University of Tokyo (SUT), Tokyo 162, Kagurazaka, Shinjuku-ku

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 31期

基金：

日本学术振兴会;

关键词：

D O I：

10.1016/0040-4039(96)01158-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Aldol reactions on solid phase have been achieved. In the presence of a catalytic amount of scandium triflate (Sc(OTf)(3)), polymer-supported silyl enol ethers reacted with aldehydes to afford the corresponding beta-hydroxy thioester derivatives, which were reduced to I,3-diol and beta-hydroxy aldehyde derivatives, or hydrolyzed to beta-hydroxy carboxylic acid derivatives. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：5569 / 5572

页数：4

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